2023年生命科学热点回眸

Research highlights of bioscience in 2023

2023年,生命科学多个领域的研究取得突破性进展。重点回顾其中一部分已经、正在和未来非常可能改变人类对生命科学研究的前沿热点:人工智能正越来越成为生命科学和医学应用的有力且重要工具;基于GLP-1激动剂的出现和空前的广泛应用;相分离、体外胚胎模型、神经科学、发育生物学等领域新的技术的进一步优化和应用;针对β-淀粉样蛋白的抗体疗法、干细胞及免疫疗法、mRNA疫苗、CRISPR基因编辑疗法等新的临床治疗手段的出现和初步临床应用。这些研究进展不但进一步拓展人类对生命本质奥秘的理解,也正在为阿尔兹海默症、肿瘤、病毒感染等一系列重大人类疾病的患者带来福音。

In 2023,breakthrough advancements were made in various fields of life sciences.This article mainly reviews some of those developments that have changed and will likely continue to change our technological,perspective,and investigative approaches to life sciences:The artificial intelligence as an increasingly powerful and important tool for applications in life sciences and medicine;The emergence and unprecedentedly widespread use of GLP-1 agonists;the further optimization and application of new technologies in areas such as phase separation,in vitro embryo models,neuroscience,and developmental biology;and the advent and initial clinical application of new clinical treatments like antibody therapy against beta-amyloid,stem cell and immunotherapy,mRNA vaccines,and CRISPR gene-editing therapies.These research advancements are not only further expanding our understanding of the mysteries of life itself but also bringing hope to patients suffering from a series of significant human diseases such as Alzheimer's,cancer,viral infections,and more.