肿瘤微环境在癌症中的动态演变过程

Dynamic evolution of tumor microenvironment in cancer

肿瘤微环境的细胞组成和功能状态可能会因肿瘤发生的器官、癌症细胞的固有特征、肿瘤分期和患者特征而大不相同。从肿瘤的发生、进展、侵袭到转移性播散和生长的各个阶段,了解肿瘤细胞内在、细胞外在和疾病进展的系统介质之间的复杂相互作用,对于合理开发有效的抗癌治疗至关重要。

The cell composition and functional status of the tumor microenvironment may vary greatly depending on the organ in which the tumor occurs,the inherent characteristics of cancer cells,tumor stage,and patient characteristics.Understanding the complex interplay between the systemic mediators of intrinsic,extracellular and disease progression of tumor cells,from all stages of tumor initiation,progression,and invasion to metastatic spread and growth,is essential for the rational development of effective anticancer therapies.