基于数据挖掘探讨李宇青治疗多囊卵巢综合征的用药规律

Exploring the Medication Rule for Li Yuqing′s Treatment of Polycystic Ovary Syndrome Based on Data Mining

目的探讨李宇青治疗PCOS的用药规律,对李宇青主任在诊治PCOS的临床经验及学术理念进行归纳。方法收集临床上符合的处方输入到Excel表格中,建立数据库,并将其导入到中医传承辅助平台系统中进行用药情况分析。结果本研究一共收集了方剂280首,中药188味,使用频率在100次以上的药物有:当归、白术、党参、香附、淫羊藿、赤芍;主要以补虚类为主,四气以温为主,五味以甘为主,多归肝经、脾经、心经、肾经、肺经。从关联规则分析得出最常用药物关联为当归-香附,从聚类分析得出高频药物核心组合为白术-党参-淫羊藿-黄芪-苍术-泽泻。结论李宇青主任治疗PCOS过程中根据患者证型不同、经期不同、肥瘦不同以及有无生育需求而辩证论治和实现个体化治疗,标实本虚,标本兼治,灵活治病。

OBJECTIVE To explore the medication rule for Li Yuqing′s treatment of Polycystic Ovary Syndrome(PCOS)and to summarize the clinical experience and academic concept of director Li Yuqing in the diagnosis and treatment of PCOS.METHODS The clinically compliant prescriptions were collected and entered into an Excel table to establish a database,which was imported into Traditional Chinese Medicine Inheritance Support System for the analysis of medicine utilization.RESULTS A total of 280 prescriptions and 188 traditional Chinese medicines were collected in this study,the medicine used more than 100 times were:Angelica sinensis,Atractylodes macrocephala,Codonopsis pilosula,Cyperus rotundus,Longspur epimedium and Red peony.These Chinese medicines were mainly in the category of tonic for deficiency,four properties were mainly warm,five flavors were mainly sweet,channel tropisms were mostly attributed to Liver Meridian,Spleen Meridian,Heart Meridian,Kidney Meridian and Lung Meridian.According to the association rule analysis,the most commonly used drug association is Angelica sinensis-Cyperus rotundus.According to the cluster analysis,the core combination of high-frequency drugs is Atractylodes macrocephala-Codonopsis pilosula-Longspur epimedium-Astragalus memeranaceus-Rhizoma atractylodis-Rhizoma alismatis.CONCLUSION In the process of treating PCOS,the treatment of director Li Yuqing based on syndrome differentiation,which realizes individualized treatment,deficiency in origin and excess in superficiality,looking into both its roots cause and symptoms,healing flexibly according to the syndrome types of different patients,the different menstrual periods,the different sizes and whether there is a need for fertility.