唐草片对艾滋病免疫功能重建不良患者的疗效观察

Observation on the Effect of Tang Herb on AIDS Patients with Poor Immune Reconstitution

目的观察唐草片联合抗反转录病毒治疗(antiretroviral therapy,ART)对艾滋病免疫功能重建不良患者的临床疗效。方法收集2021年6月—2022年12月于贵阳市公共卫生救治中心治疗的艾滋病免疫功能重建不良患者共247例。其中70例使用抗反转录病毒药物治疗,177例在维持其原有抗反转录病毒药物治疗方案基础上联合唐草片,试验周期6个月,收集患者的一般资料以及治疗期间的CD4^(+)T淋巴细胞计数、HIV病毒载量、肝肾功能等安全性和疗效性指标。结果联合治疗组患者CD4^(+)T淋巴细胞计数上升;CD4^(+)T淋巴细胞计数<200个/μL的患者治疗后CD4^(+)T淋巴细胞计数上升幅度最大。联合治疗组患者的免疫功能改善优于单独抗病毒药物组。治疗期间病毒载量低于检测下限。结论艾滋病免疫功能重建不良患者在维持原有抗反转录病毒治疗药物的基础上联合唐草片,可以改善患者的免疫功能重建不良,并且可以降低抗病毒药物的不良反应,提高患者的生存质量。

Objective To observe the clinical effect of Tang Herb combined with antiretroviral therapy(ART)in the treatment of AIDS patients with poor immune reconstitution.Methods A total of 247 patients with poor immune function reconstruction of AIDS who were treated in Guiyang Public Health Clinical Center from June 2021 to December 2022 were collected.Among them,70 patients were treated with antiretroviral therapy,and 177 patients were treated with Tang Herb on the basis of maintaining their original antiretroviral therapy regimen.The test period was 6 months.The general data of the patients and the safety and efficacy indicators such as CD4^(+)T lymphocyte count,HIV viral load,liver and kidney function during treatment were collected.Results The CD4^(+)T lymphocyte count increased in the combined treatment group.Patients with CD4^(+)T lymphocyte count less than 200 cells/μL had the largest increase in CD4^(+)T lymphocyte count after treatment.The improvement of immune function in the combined treatment group was better than that in the ART group.The viral load during treatment was lower than the detection limit.Conclusion AIDS patients with poor immune function reconstruction combined with Tang Herb on the basis of maintaining the original ART regimen can improve the poor immune function reconstruction of patients,and can reduce the adverse reactions of antiviral drugs and improve the quality of life of patients.