普雷沃氏菌在细菌性阴道病和人乳头瘤病毒持续感染中的研究进展

Progress of Prevotella in bacterial vaginosis and persistent human papilloma virus infection

细菌性阴道病中相关微生物可能导致人乳头瘤病毒(HPV)感染甚至持续感染,同时HPV感染能促进细菌性阴道病的发生。最近研究发现细菌性阴道病相关微生物普雷沃氏菌(普氏菌)与HPV持续感染密切相关。普氏菌是阴道常见的共生菌,它是一种专性厌氧菌,培养困难,也很少受到关注,随着基因测序工程技术越来越成熟,普氏菌在妇科疾病中的重要性也越来越突出。已有研究表明普氏菌可能是生殖道炎症发生时的早期定植菌群,为其他细菌、病毒入侵生殖道奠定基础。笔者总结了近年来普氏菌在细菌性阴道病和HPV持续感染中的研究进展,增强对普氏菌的了解,为HPV感染和相关疾病的预防和治疗提供参考。

Microorganisms associated with bacterial vaginosis(BV)potentially contribute to human papilloma virus(HPV)infection and even persistent infection,while HPV infection can facilitate the progression of bacterial vaginosis.Recently,Prevotella has been identified to be intimately tied to persistent HPV infection.Prevotella,as a common commensal in the vagina,is a specialized anaerobic bacterium that is difficult to culture and has received scant attention.With more sophisticated technology for genetic sequencing engineering.Prevotella has acquired prominence in gynecological diseases.It has been documented that Prevotella might be an early colonizing flora at the onset of inflammation in the genital tract,which facilitates the invasion of other bacteria and viruses into the genital tract.The authors summarize the research progress in recent years in the role of Prevotella in bacterial vaginosis and persistent HPV infection,with the aim to better understand Prevotella and to provide reference for the prevention and treatment of HPV infection and related diseases.