基于“胃喜润恶燥”理论探讨胃酸分泌减少对胃内微生态系统的影响

Exploring the Impact of Reduced Gastric Acid Secretion on the Gastric Microecosystem Based on the Theory of“Stomach Liking Moistness and Disliking Dryness”

中医学认为,胃是阳明燥土之腑,易阳亢而生燥热,需胃中津液的不断滋养濡润,才能维持其正常生理功能,若胃中津液不足,失于润养就易引发胃的病变,故言胃有“喜润恶燥”的生理特性。笔者基于该理论,通过深入探讨人体胃酸分泌对胃内微生态系统的影响后发现,胃酸分泌减少不仅能引起胃内大量致病菌的滋生,破坏胃内微生态环境,造成胃部感染,还可抑制胃蛋白酶的产生,导致消化不良。进而从现代医学角度揭示了“胃喜润恶燥”理论的科学内涵,使中医辨证更趋微观化,临床论治更加精准化,选方用药更为高效化。

Traditional Chinese medicine(TCM)believes that the stomach is a bowel of yang brightness meridian and pertains to dry earth,which tends to have yang hyperactivity and dryness heat.It therefore,requires continuous nourishment and moistening of the stomach fluid to maintain its normal physiological function.If there is insufficient stomach fluid,the stomach will lose the nourishment from the fluid,and the patient may get gastric lesion.Therefore,the stomach has a physiological characteristic of“liking moistness and disliking dryness”.Based on this theory,the authors found through in-depth exploration of the impact of human gastric acid secretion on the gastric microbiota that a decrease in gastric acid secretion can not only cause the breeding of a large number of pathogenic bacteria in the stomach,damage the gastric microbiota,and cause stomach infections,but also inhibit the production of pepsin,leading to indigestion.Therefore,from the perspective of modern medicine,we have revealed the scientific connotation of the theory of“stomach liking moistness and disliking dryness”,making TCM differentiation more microscopic,clinical treatment more precise,and medication selection more efficient.