化痰排瘀针刺法联合自拟止颤方治疗血管性帕金森综合征的临床效果

Clinical effect of Huatan Paiyu acupuncture combined with self-made Zhichan formula in the treatment of vascular parkinsonism

目的观察化痰排瘀针刺法联合自拟止颤方治疗血管性帕金森综合征(VP)的临床效果。方法选择2019年9月至2020年12月收治的72例VP患者作为研究对象,采用随机数字表法将其分为对照组和治疗组,各36例。对照组单用多巴丝肼片治疗,治疗组采用化痰排瘀针刺法联合自拟止颤方治疗。比较两组的治疗效果。结果治疗组的治疗总有效率显著高于对照组(P<0.05)。治疗后,治疗组的美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,脑源性神经营养因子(BDNF)、神经生长因子(NGF)水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,治疗组的Webster评分、跌倒次数低于对照组,Berg平衡量表(BBS)评分及6 min步行距离(6MWD)高于对照组,差异具有统计学意义(P<0.05)。治疗组的不良反应总发生率低于对照组,差异具有统计学意义(P<0.05)。结论化痰排瘀针刺法联合自拟止颤方治疗VP的效果显著,可改善患者的神经功能,促进症状恢复,且安全性更高。

Objective To observe the clinical effect of HuatanPaiyu acupuncture combined with self-made Zhichan formula in the treatment of vascular parkinsonism(VP).Methods A total of 72 VP patients admitted from September 2019 to December 2020 were selected as the research objects and divided into control group and treatment group by random number table method,with 36 cases in each group.The control group was treated with levodopa and benserazide tablets alone,and the treatment group was treated with Huatan Paiyu acupuncture combined with self-made Zhichan formula.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the treatment group was significantly higher than that in the control group(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score of the treatment group was lower than that of the control group,and the levels of brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)were higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the Webster score and number of falls in the treatment group were lower than those in the control group,and the Berg Balance Scale(BBS)score and 6 min walking distance(6MWD)were higher than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Huatan Paiyu acupuncture combined with self-made Zhichan formula in the treatment of VP has significant effect,which can improve the neurological function of patients and promote the recovery of symptoms,with higher safety.