中药保留灌肠联合益脾理肠汤内服治疗慢性结肠炎的效果及对炎症反应的影响

Effect of traditional Chinese medicine retention enema combined with Yipi Lichang decoction for oral administration in the treatment of chronic colitis and its influence on inflammatory response

目的分析中药保留灌肠联合益脾理肠汤内服治疗慢性结肠炎的临床价值。方法以2018年1月至2022年1月收治的86例慢性结肠炎患者为研究对象,根据随机数字表法将其分为对照组(n=43,常规治疗)和研究组(n=43,常规治疗+中药保留灌肠+益脾理肠汤内服)。比较两组的治疗效果。结果研究组的治疗总有效率显著高于对照组(P<0.05)。治疗后,研究组的内毒素(BT)、D-乳酸(D-LA)及二胺氧化酶(DAO)水平显著低于对照组(P<0.05)。治疗后,研究组的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、细胞间黏附分子-1(ICAM-1)、基质金属蛋白酶-9(MMP-9)及中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平显著低于对照组(P<0.05)。治疗后,研究组的CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。结论中药保留灌肠联合益脾理肠汤内服治疗慢性结肠炎的效果显著,有助于控制机体炎症反应,改善免疫功能,进而促进肠黏膜屏障功能恢复,值得推广。

Objective To analyze the clinical value of traditional Chinese medicine retention enema combined with Yipi Lichang decoction for oral administration in the treatment of chronic colitis.Methods A total of 86 patients with chronic colitis admitted from January 2018 to January 2022 were selected as the study objects.According to random number table method,the patients were divided into control group(n=43,conventional treatment)and study group(n=43,conventional treatment+traditional Chinese medicine retention enema+Yipi Lichang decoction for oral administration).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was significantly higher than that of the control group(P<0.05).After treatment,the levels of bacterial endotoxin(BT),D-lactic acid(D-LA)and diamine oxidase(DAO)in the study group were significantly lower than those in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),intercellular cell adhesion molecule-1(ICAM-1),matrix metalloproteinase 9(MMP-9)and neutrophil gelatinase-associated lipocalin(NGAL)in the study group were significantly lower than those in the control group(P<0.05).After treatment,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the study group were higher than those in the control group,and CD8^(+)was lower than that in the control group(P<0.05).Conclusion Traditional Chinese medicine retention enema combined with Yipi Lichang decoction in the treatment of chronic colitis has a remarkable effect,it helps to control body's inflammatory response,improve immune function,and further promote the recovery of intestinal mucosal barrier function,which is worthy of promotion.