摘要
目的优选并确立苦参止痒膏的最佳制备工艺。方法采用水煎煮法,选择加水量、浸泡时间、煎煮时间为考察因素,以浸膏得率为评价指标,采用L_(9)(3^(4))正交试验优选提取条件;以油相用量、载药量、乳化剂用量为自变量,设计苦参止痒膏制备工艺的响应面试验,确定最佳制备条件。结果苦参止痒膏最优提取工艺为10倍的水,浸泡处方4 h,煎煮2 h;乳膏最佳制备工艺为油相用量10%(g·g^(-1)),载药量2.5%(g·g^(-1)),乳化剂用量为5.0%(g·g^(-1)),所制得的乳膏质量和性状最好。结论新的制备工艺简便、稳定可行,模型预测功能良好,可为中药新药的开发及工业化放大生产提供参考。
OBJECTIVE To optimize and establish the preparation process of KuShen ZhiYang Cream.METHODS Use water boiling method,choose the amount of water,soak time,and decoction time as the investigation factor,take the extraction yield as the evaluation indicator,and use the L_(9)(3^(4))orthogonal test to prefer the extraction conditions;Based on the amount of oil phase,the amount of medicine,and the amount of emulsifiers as the independent variable,design the response surface test of the KuShen ZhiYang Cream preparation process to determine the best preparation conditions.RESULTS The best preparation process was as follow:the medicinal materials were soaked for 240 min,extracted with 10 times of extraction solvent,120 min each time.KuShen ZhiYang Cream with oil content 10%(g·g^(-1)),the drug loading 2.5%(g·g^(-1)),emulsifier dosage 6%(g·g^(-1)),the quality and properties of KuShen ZhiYang Cream were the best.CONCLUSION This new preparation technology is simple,stable and feasible,and the model prediction function is good,which can provide reference for the development and industrial scale-up production of new Chinese medicines.
作者
韩冰洋
游烨
李建华
HAN Bing-yang;YOU Ye;LI Jian-hua(Xiangyang Integrated Traditional Chinese and Western Medicine Hospital,Xiangyang 441004,China)
出处
《海峡药学》
2024年第3期1-5,共5页
Strait Pharmaceutical Journal
基金
襄阳市2021年度医疗卫生领域科技计划(2021ZD25)。
关键词
苦参止痒膏
提取工艺
制备工艺
正交试验
星点设计-响应面法
KuShen ZhiYang Cream
Extraction process
Preparation process
Orthogonal method
Central composite design-response surface methodology