药学干预对2型糖尿病患者治疗效果的影响

Effect of Pharmaceutical Intervention on the Therapeutic Effect of Outpatients with Type 2 Diabetes

目的探讨药学干预对门诊就诊的2型糖尿病患者治疗效果的影响。方法选取2021年12月~2022年4月蚌埠市第二人民医院门诊就诊的2型糖尿病患者200例,其中男109例、女81例,年龄39~80(58.9±5.0)岁。按随机数字表法将患者分为干预组与对照组,每组100例。对照组采取常规医疗服务进行用药指导。干预组在常规医疗服务进行用药指导的基础上实行药学干预,包括宣讲疾病知识、用药指导和定期随访等措施。随访12个月,比较两组患者2型糖尿病空腹血糖(FPG)、餐后2h血糖(2h PG)、糖化血红蛋白(HbAlc)水平、收缩压、舒张压、BMI等主要指标控制情况。评估两组对相关知识的了解及用药依从性的改善情况。结果两组患者基线资料比较差异无统计学意义(P>0.05)。随访12个月,两组FPG、2h PG、HbAlc、收缩压、舒张压、BMI均低于开始治疗前。与对照组比较,干预组优于对照组,差异有统计学意义(P<0.05)。干预后两组糖尿病认知问卷及用药依从性评分均提高,但干预组与干预前比较均有显著差异(P<0.05),对照组与干预前得分差异均无统计学意义(P>0.05)。结论药师对2型糖尿病患者进行药学干预,有助于加强患者对疾病和合理用药的认识,提高用药依从性。在保证患者用药的安全性和有效性的同时,提升药师的作用和价值。

OBJECTIVE To explore the effect of pharmaceutical intervention on the therapeutic effect of outpatients with type 2 diabetes.METHODS A total of 200 patients with type 2 diabetes mellitus were selected from the outpatient clinic of the second people′s Hospital of Bengbu from December 2021 to April 2022,including 109 males and 81 females,aged from 39 to 80(58.9±5.0)years.The patients were randomly divided into intervention group(n=100)and control group(n=100).The control group took routine medical services to guide the use of drugs.Pharmaceutical intervention was carried out in the intervention group,including publicity of disease knowledge,medication guidance and regular follow-up.During the follow-up of 12 months,the control of FPG,2h PG,HbAlc,systolic blood pressure,diastolic blood pressure and BMI of type 2 diabetes were compared between the two groups.To evaluate the understanding of relevant knowledge and the improvement of medication compliance between the two groups.RESULTS There was no significant difference in baseline data between the two groups(P>0.05).During the follow-up of 12 months,FPG,2h PG,HbAlc,systolic blood pressure,diastolic blood pressure and BMI in both groups were lower than those before treatment.Compared with the control group,the intervention group was better than the control group,the difference was statistically significant(P<0.05).After intervention,the scores of diabetes cognition questionnaire and medication compliance in the two groups were improved,but there were significant differences between the intervention group and before the intervention(P<0.05),and there was no significant difference between the control group and before the intervention(P>0.05).CONCLUSION Pharmacist intervention in patients with type 2 diabetes can help strengthen patients′awareness of the disease and rational drug use,and improve drug compliance.It can not only ensure the safety and effectiveness of patients,but also enhance the role and value of pharmacists.