前列舒通胶囊联合索利那新治疗老年良性前列腺增生合并膀胱过度活动症术后疗效及其影响因素分析

Postoperative Efficacy and Influencing Factors of Qianlie Shutong Capsules Combined with Solifenacin in the Treatment of Elderly Patients with Benign Prostatic Hyperplasia Complicated with Overactive Bladder

目的探讨前列舒通胶囊联合索利那新治疗老年良性前列腺增生(BPH)合并膀胱过度活动症(OAB)术后的临床疗效,并分析影响疗效的相关因素。方法回顾性选取医院泌尿外科2020年3月至2023年3月收治的老年BPH合并OAB患者102例,根据用药方案的不同分为对照组(49例)和观察组(53例)。两组患者均口服琥珀酸索利那新片,观察组患者加用前列舒通胶囊,均连续治疗2个月。比较两组患者的总有效率,以及最大尿流率(Qmax)、残余尿量(PVR)、国际前列腺症状评分(IPSS)、BPH生活质量(BPHQOL)评分、OAB症状量表(OABSS)评分。采用单因素方差分析影响前列舒通胶囊治疗老年BPH合并OAB术后疗效的相关因素,并采用多因素Logistic分析其独立危险因素。结果观察组总有效率为90.57%,显著高于对照组的71.43%(P<0.05)。治疗后,两组患者Qmax显著升高,PVR显著降低,IPSS评分、BPHQOL评分、OABSS评分均显著降低(P<0.001),且观察组显著优于对照组(P<0.01)。观察组和对照组患者不良反应发生率相当(32.08%比40.82%,P>0.05)。单因素方差分析结果显示,术前IPSS评分、OABSS评分、前列腺体积、PVR与术中出血量均为影响前列舒通胶囊疗效的相关因素(P<0.05)。多因素Logistic回归分析结果显示,术前前列腺体积、IPSS评分与PVR为独立危险因素(P<0.05)。结论前列舒通胶囊联合索利那新治疗老年BPH合并OAB术后的临床疗效较好,可有效改善患者生活质量。术前前列腺体积、IPSS评分与PVR对老年BPH合并OAB患者的临床疗效有一定预测价值。

Objective To investigate the postoperative efficacy of Qianlie Shutong Capsules combined with Solifenacin in the treatment of elderly patients with benign prostatic hyperplasia(BPH)complicated with overactive bladder(OAB),and to analyze the relevant factors affecting the efficacy.Methods A total of 102 elderly patients with BPH complicated with OAB admitted to the Urology Department of the hospital from March 2020 to March 2023 were retrospectively selected and divided into the control group(49 cases)and the observation group(53 cases)according to different treatment medication regimens.The patients in the two groups were orally administered Solifenacin Succinate Tablets,on this basis,the patients in the observation group were treated with Qianlie Shutong Capsules.Both groups were treated continuously for two months.The total effective rate,maximum urinary flow rate(Qmax),postvoid residual urine(PVR),International Prostate Symptom Score(IPSS),Quality of Life Scale for Benign Prostatic Hyperplasia(BPHQOL),and Symptom of Overactive Bladder Symptom Scale(OABSS)in two groups were compared.One-way analysis of variance(ANOVA)was used to identify the relevant factors affecting the postoperative efficacy of Qianlie Shutong Capsules in elderly patients with BPH complicated with OAB,and multivariate Logistic regression analysis was used to identify independent risk factors of the relevant factors.Results The total effective rate in the observation group was 90.57%,which was significantly higher than 71.43% in the control group(P<0.05).After treatment,the Qmax significantly increased,while the PVR,IPSS score,BPHQOL score,and OABSS score significantly decreased in the two groups(P<0.001),and those in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was comparable to that in the control group(32.08%vs.40.82%,P>0.05).The results of one-way ANOVA showed that preoperative IPSS score,OABSS score,prostate volume,PVR,and intraoperative bleeding were relevant factors affecting the efficacy of Qianlie Shutong Capsules(P<0.05).Multivariate Logistic regression analysis showed that prostate volume,preoperative IPSS score,and PVR were independent risk factors(P<0.05).Conclusion Qianlie Shutong Capsules combined with solifenacin have good clinical efficacy in the treatment of postoperative elderly patients with BPH complicated with OAB,and can effectively improve the quality of life.The patient's prostate volume,preoperative IPSS score,and PVR have certain predictive value for clinical efficacy of elderly patients with BPH complicated with OAB.