代谢组学技术在骨质疏松症中的应用研究进展

Research Progress on the Application of Metabolomics Techniques in Osteoporosis

目的总结代谢组学技术在骨质疏松症中的应用情况。方法检索万方、PubMed数据库自建库起至2023年5月有关代谢组学技术用于骨质疏松症的发病机制、诊断及防治的文献。结果骨质疏松症主要由氨基酸、脂质、能量等的代谢紊乱引起,其差异代谢物均可作为疾病预测、诊断、治疗的生物标志物。代谢组学与多组学的联用是目前的研究热点。结论代谢组学具有巨大的临床翻译潜力,从疾病预测到治疗,为进行全面的骨质疏松症研究提供了新的方向。

Objective To summarize the application of metabolomics techniques in osteoporosis.Methods Relevant studies on the application of metabolomics techniques in the pathogenesis,diagnosis,and prevention of osteoporosis in databases such as WanFang and PubMed from the inception of databases to May 2023 were searched.Results Osteoporosis is mainly disordered by amino acid metabolism,lipid metabolism,and energy metabolism,among which differential metabolites can be used as biomarkers for disease prediction,diagnosis and treatment.The combined application of metabolomics and multi-omics is a research hotspot in recent years.Conclusion Metabolomics has great clinical translation potential,from disease prediction to treatment,which provids a new direction for comprehensive research on osteoporosis.