氮杂环卡宾催化的五氟苯基硫醚的合成

N-Heterocyclic Carbene-Catalyzed Synthesis of Pentafluorophenyl Sulfides

利用氮杂环卡宾催化剂的强Lewis碱性,发展了一种构建C(sp^(2))—S键的有效方法.稳定的氮杂环卡宾1,3-双(2,6-二异丙基苯基)咪唑-2-亚基可以对五氟苯基三甲基硅烷的C—Si键进行有效活化,进而引发与硫代磺酸酯的亲核取代反应,以34%~98%的产率生成五氟苯基硫醚产物.

An efficient method for the construction of C(sp^(2))—S bond has been developed.The stable N-heterocyclic carbene 1,3-bis(2,6-dissopropylphenyl)-imidazole-2-ylidene can activate the C—Si bond of pentafluorophenyl trimethylsilicon effectively to initiate the nucleophilic substitution reaction with thiosulfonic ester,producing pentafluorophenyl sulfide products in 34%~98%yields.