胆道闭锁小儿肝移植手术时机、术式和疗效

Timing,procedures and efficacy of liver transplantation in children with biliary atresia

胆道闭锁是由于肝外与肝内胆管发生进行性纤维炎性梗阻而导致的胆汁淤积性肝硬化,并最终以肝衰竭为结局的一类疾病,是小儿肝移植手术的常见适应证。本文将探讨胆道闭锁的发病机制、诊断方法、肝移植手术时机、手术方式及术后并发症;同时探讨小儿肝移植的现状及发展。

Biliary atresia is a category of disease caused by biliary cirrhosis due to progressive fibro-inflammatory obstruction of extrahepatic and intrahepatic bile ducts,and eventually progresses into liver failure.It is a common indication for liver transplantation in children.In this article,the pathogenesis,diagnosis of biliary atresia,timing,procedures and postoperative complications of liver transplantation were illustrated.Meantime,current status and development of pediatric liver transplantation were discussed.