整合素β3通过激活MAPK/ERK途径促进鼻咽癌细胞转移

Integrinβ3 promotes metastasis of nasopharyngeal carcinoma cells by activating the MAPK/ERK pathway

鼻咽癌(NPC,nasopharyngeal carcinoma)作为我国南方及东南亚地区高发的一种头颈部恶性肿瘤,远端转移和局部复发是导致其治疗失败的主要原因。本研究通过对不同转移能力的鼻咽癌细胞进行分析,发现整合素β3(ITGB3,integrinβ3)在高转移鼻咽癌细胞中的表达明显高于低转移鼻咽癌细胞。随后的研究表明ITGB3的上调表达促进了鼻咽癌细胞迁移、侵袭、克隆形成以及黏附能力,同时促进了鼻咽癌细胞增殖并抑制其凋亡水平。进一步地,本研究发现,ITGB3主要通过激活MAPK/ERK途径,进而促进鼻咽癌细胞迁移、侵袭、克隆形成以及黏附。因此,研究揭示了ITGB3对鼻咽癌细胞转移的调控作用及其分子机制,为鼻咽癌细胞转移防治与治疗提供了新的理论基础。

Nasopharyngeal carcinoma(NPC)is a prevalent head and neck malignancy in South China and Southeast Asia,often leading to treatment failure due to distal metastasis and local recurrence.This study showed a significant increase in the expression of integrinβ3(ITGB3)in highly metastatic NPC cells compared to poorly metastatic NPC cells.This study further elucidates that upregulation of ITGB3 expression not only enhances the migratory,invasive,clonogenic,and adhesive capacities of NPC cells,but also promotes their proliferation and inhibiting apoptosis.Mechanistically,ITGB3 primarily activates the MAPK/ERK pathway,as a result,enhancing the migratory,invasive,clonogenic,and adhesive capabilities of NPC cells.These findings in the study reveal the regulatory effect and molecular mechanism of ITGB3 on NPC cell metastasis,providing a new theoretical basis for the prevention and treatment of NPC cell metastasis.