柴芍胃康汤联合四联疗法治疗肝胃气滞证Hp阳性慢性萎缩性胃炎的疗效观察

Efficacy of Chaishao Weikang Decoction Combined with Quadruple Therapy on Helicobacter Pylori Positive Chronic Atrophic Gastritis of Liver Stomach Qi Stagnation Syndrome

目的:观察柴芍胃康汤联合四联疗法治疗肝胃气滞证幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)的疗效及对患者胃泌素-17(G-17)、丙二醛(MDA)、胃蛋白酶原(PG)Ⅰ和PGⅡ水平,胃黏膜组织病理和Hp根除的影响。方法:选取2021年6月至2023年5月该院收治的肝胃气滞证Hp阳性CAG患者140例,按随机数字表法分为联合组和对照组(各70例)。对照组患者给予标准四联疗法,联合组患者在对照组的基础上给予柴芍胃康汤治疗。比较两组患者治疗前后血清G-17、MDA、PGⅠ和PGⅡ水平,胃黏膜组织病理评分、Hp根除率,观察安全性和临床疗效。结果:治疗后,两组患者血清G-17、PGⅠ水平明显升高,MDA、PGⅡ水平和胃黏膜组织病理评分明显降低;且联合组患者血清G-17、PGⅠ水平较对照组升高,MDA、PGⅡ水平和胃黏膜组织病理评分较对照组降低,差异均有统计学意义(P<0.05)。联合组患者的Hp根除率、总有效率分别为92.86%(65/70)、92.86%(65/70),明显高于对照组的81.43%(57/70)、81.43%(57/70),差异均有统计学意义(P<0.05)。结论:柴芍胃康汤联合四联疗法治疗肝胃气滞证Hp阳性CAG的疗效较好,可改善患者胃功能、氧化应激和胃黏膜组织病理损伤,并可有效提高Hp根除率。

OBJECTIVE:To observe the efficacy of Chaishao Weikang decoction combined with quadruple therapy on Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG)of liver stomach Qi stagnation syndrome and its effects on levels of gastrin 17(G-17),malondialdehyde(MDA),pepsinogen(PG)Ⅰ,PGⅡ,gastric mucosa tissue pathology and eradication of Hp.METHODS:A total of 140 patients with Hp positive CAG of liver stomach Qi stagnation syndrome admitted into Handan Traditional Chinese Medicine Hospital from Jun.2021 to May 2023 were extracted to be divided into the combined group and control group(with 70 cases in each group)via random number table method.The control group was given standard quadruple therapy,while combined group received Chaishao Weikang decoction on the basis of the control group.Serum levels of G-17,MDA,PGⅠand PGⅡ,gastric mucosal histopathological score,Hp eradication rate before and after treatment of two groups were compared,safety and clinical efficacy were observed.RESULTS:After treatment,serum levels of G-17 and PGⅠincreased significantly,while levels of MDA and PGⅡand gastric mucosal histopathologic scores decreased significantly in two groups;and serum levels of G-17 and PGⅠin combined group were higher than those in control group,while levels of MDA and PGⅡand gastric mucosal histopathologic scores were lower than those in control group,with statistically significant differences(P<0.05).The eradication rate and total effective rate of Hp in combined group were respectively 92.86%(65/70)and 92.86%(65/70),significantly higher than 81.43%(57/70)and 81.43%(57/70)in control group,the differences were statistically significant(P<0.05).CONCLUSIONS:The efficacy of Chaishao Weikang decoction combined with quadruple therapy on Hp positive CAG of liver stomach Qi stagnation syndrome is significant,which can improve gastric function,oxidative stress,and pathological damage to gastric mucosa tissue,and effectively increase the Hp eradication rate.