特发性肺纤维化病机探微

Pathogenesis of Idiopathic Pulmonary Fibrosis

特发性肺纤维化是慢性虚损性肺系疾病,病因不明,证候复杂,病情常迁延不愈。从中医五脏一体观理论探析特发性肺纤维化病机特点可知,该病的发生归结于五脏功能失调,以肺、脾、肾为主轴,兼顾肝、心;其发病的演变规律为肺病传脾,脾虚痰瘀,继而肺病及肾,肺肾亏虚,后期累及肝、心。痰、瘀贯穿疾病的始终,是病理产物,亦是致病因素。因此,应从“五脏一体观”理论出发治疗特发性肺纤维化,整体防治,气血同调,以平为期,未病先防,既病防变。

Idiopathic pulmonary fibrosis is a chronic debilitating pulmonary disease with unknown etiology,complex syndromes,and prolonged disease progression.By analysis of the theory of"Five Zang integration"in traditional Chinese medicine,it can be concluded that the pathogenesis of idiopathic pulmonary fibrosis is attributed to dysfunction of the Five Zang,in which the Lung,Spleen and Kidney as the main axis while the Liver and Heart should also be taken into account.The evolutionary pattern of its onset is that the Lung disease spreads to the Spleen,and with Spleen deficiency and Phlegm stasis,the Lung disease affects the Kidney.The deficiency of Lung and Kidney would injure Liver and Heart.Phlegm and blood stasis are pathological products and the pathogenic factors that run through the entire process of the disease.Therefore,the treatment of idiopathic pulmonary fibrosis should be based on the theory of"Five Zang integration,with overall preventing and treating,coordinating Qi and blood to achieve a balanced condition.Prevention should be made before the onset of the disease,and prevention should also be made before the transmission of the disease.