食物对口服靶向抗肿瘤药物代谢影响的研究进展

Research Progress of the Effect of Food on the Metabolism of Oral Targeted Antitumor Drug

部分食物对口服靶向抗肿瘤药物的代谢具有临床意义的影响,包括:西柚可影响尼罗替尼、舒尼替尼、伊马替尼、克唑替尼、达沙替尼、厄洛替尼、拉帕替尼、帕唑帕尼、依维莫司、奥拉帕利、塞瑞替尼、凡德他尼、阿昔替尼的代谢;酸橙可影响奥拉帕利的代谢;蔓越莓对伊马替尼、生姜对克唑替尼、苹果对厄洛替尼、人参对伊马替尼及达沙替尼、芹菜对达沙替尼、烟草对厄洛替尼的代谢存在影响;合并使用质子泵抑制剂时,可乐可影响厄洛替尼的代谢。临床用药需要重视食物对口服靶向抗肿瘤药物代谢的影响,注意合理搭配药物与食物,保障药物的有效性和安全性。

Some foods have certain clinical significance on the metabolism of oral targeted anti-tumor drugs.Grapefruit had an effect on the metabolism of nilotinib,sunitinib,imatinib,crizotinib,dasatinib,erlotinib,lapatinib,pazopanib,everolimus,olaparib,ceritinib,vandetanib,axitinib;lime had effects on olaparib metabolism,cranberry on imatinib metabolism,ginger on crizotinib metabolism,apple on erlotinib metabolism,ginseng on imatinib and dasatinib metabolisms,celery on dasatinib metabolism,and tobacco on erlotinib metabolism.Cola combined with proton pump inhibitor had an effect on erlotinib metabolism.It is necessary to pay attention to the effect of food on the metabolism of oral targeted anti-tumor drugs,and rationally match drugs with food to ensure the efficacy and safety of drugs.