柴胡疏肝汤加减治疗乙型肝炎患者的药学作用研究

Pharmacological Effect Study of Modified Bupleurum Liver-Coursing Decoction for Hepatitis B Patients

目的评价柴胡疏肝汤加减治疗乙型肝炎患者的药学作用。方法选取2021年7月—2022年12月来本院就诊治疗的乙型肝炎患者,筛选出符合标准的68例遵循随机数表法分组,对照组34例,行常规西药治疗,观察组34例,行柴胡疏肝汤加减治疗,对比两组生活质量、肝功能指标、中医证候积分、临床疗效以及不良反应情况。结果观察组患者治疗后随访期间的各方面生活质量评分显著高于对照组,统计差异有意义(P<0.05)。治疗前,两组患者的各项肝功能指标(谷丙转氨酶、谷氨酰转肽酶、谷草转氨酶、白蛋白、总胆红素)差异无统计学意义(P>0.05);治疗后,观察组患者的各项肝功能指标改善显著优于对照组,组间差异有统计意义(P<0.05)。相比于对照组,观察组患者治疗后的各项中医症状积分均显著偏低,其治疗的不良反应发生率偏低,组间差异有统计学意义(P<0.05)。观察组治疗后取得的总有效率显著比对照组高,组间差异有统计学意义(P<0.05)。结论临床治疗乙型肝炎选择柴胡疏肝汤加减治疗的疗效显著,用药安全性高,对改善其肝功能和促使患者尽快恢复日常生活具有积极作用,值得临床采纳。

Objective To evaluate pharmacological effect of modified bupleurum liver-coursing decoction for hepatitis B patients.Methods The paper collected research data from July 2021 to December 2022,and chose 68 hepatitis B patients met standards in our hospital as survey subjects,and divided them into groups according to random number table method.34 cases in control group who were treated with routine western medicine treatment,while 34 cases in observation group with modified bupleurum liver-coursing decoction treatment.Life quality,liver function indicators,traditional Chinese medicine syndrome scores,clinical effect,and adverse reactions between two groups were compared.Results Life quality scores of observation group during follow-up period after treatment were significantly higher than control group,with statistical significance(P<0.05).Difference in various liver function indicators between two groups before treatment showed(P>0.05),various liver function indicators(alanine aminotransferase,alanine aminotransferase,alanine aminotransferase,albumin,total bilirubin)of observation group after treatment were significantly better than control group,with statistical significance(P<0.05).Observation group had significantly lower scores of various traditional Chinese medicine symptoms after treatment than control group,incidence of adverse reactions during treatment was lower,with significant difference between groups(P<0.05).total effective rate in observation group after treatment was,significantly higher than control group,with statistical significance(P<0.05).Conclusion Modified bupleurum liver-coursing decoction can achieve significant curative effect and high medication safety in clinical treatment of hepatitis B,with positive effect on improving liver function and daily life recovery as soon as possible,which is worthy of clinical adoption.