细胞外容积分数在胰腺疾病中的研究进展

Advances in study of extracellular volume fraction in pancreatic diseases

目的总结基于影像学检查获得的细胞外容积(extracellular volume,ECV)在胰腺疾病中的应用现状及研究进展。方法查阅国内外近年来ECV相关研究的文献,包括基于计算机断层扫描和磁共振成像计算得出的ECV在胰腺炎症、肿瘤性、纤维化病变等疾病中的相关临床研究,并进行归纳总结。结果胰腺由于解剖位置特殊,其纤维化程度活检诊断在技术上具有挑战性。ECV是对细胞外基质的量化,细胞外基质在肿瘤增殖和侵袭过程中具有调节作用,在组织纤维化进程中胶原纤维的产生和细胞外基质沉积可增加细胞外间隙,因此基于影像学检查得到的ECV不仅能避免有创检查,还可反映肿瘤微环境状态并评估组织纤维化程度。ECV可作为一种新型影像学定量指标评价胰腺疾病。结论根据当前对ECV在胰腺相关疾病中的研究现状及进展情况的综述,ECV作为一种非侵袭性的生物标志物,被越来越多地应用于胰腺相关的多种疾病,可预测肿瘤分级、纤维化程度、化学药物治疗后反应、癌症患者生存等,具有较好的临床应用研究前景。

Objective To summarize the current application status and research progress of extracellular volume(ECV)fraction based on imaging examinations in pancreatic diseases.Method The literature relevant to research was summarized,including the clinical studies of the ECV fraction that based on computed tomography and magnetic resonance imaging in pancreatic inflammation,neoplastic lesions,fibrosis,and other diseases.Results Biopsy of pancreas was technically challenging due to its unique anatomical location.The ECV fraction was the quantitative index of extracellular matrix that played a regulatory role in the process of tumor proliferation and invasion.And the production of collagen fibers and the deposition of extracellular matrix could increase the extracellular space in the progression of tissue fibrosis.Therefore,the ECV fraction obtained based on imaging examination could not only avoid invasive examination,but also reflect the status of tumor microenvironment and evaluate the degree of tissue fibrosis.The ECV fraction had the potential to serve as a novel quantitative imaging evaluation index for pancreatic diseases.Conclusions According to the current research status and progress of ECV fraction in pancreatic-related diseases,ECV fraction is increasingly being utilized as a non-invasive biomarker across various pancreatic-related conditions.It holds the potential to predict tumor grading,degree of fibrosis,post-chemotherapy response,cancer patient survival,etc.Consequently,it exhibits promising prospects for clinical application research.