摘要
心肌损伤是由多种因素引起的心肌病理改变,可导致心功能下降及心血管事件的发生。黄芪甲苷是黄芪主要药理成分之一,通过调控多种信号通路发挥抗心肌损伤作用。本文从抑制氧化应激、抑制细胞凋亡、抗心肌纤维化、改善心肌能量代谢及抑制心肌炎症反应方面对黄芪甲苷抗心肌损伤作用机制进行综述,为相关机制研究及临床应用提供参考。
Myocardial injury is a pathological change of myocardium caused by many factors,which can lead to the decline of cardiac function and the occurrence of cardiovascular events.AstragalosideⅣis one of the main pharmacological components in Astragali Radix,which plays an anti-myocardial injury role by regulating various signaling pathways.This article reviewed the anti-myocardial injury mechanism of astragalosideⅣfrom five aspects:inhibition of oxidative stress,inhibition of apoptosis,anti-myocardial fibrosis,improvement of myocardial energy metabolism and inhibition of myocardium inflammation,in order to provide reference for the mechanism research and clinical application of astragalosideⅣin the prevention and treatment of myocardial injury.
作者
王旭勇
赵信科
蒋虎刚
王春玲
张晓刚
李应东
WANG Xuyong;ZHAO Xinke;JIANG Hugang;WANG Chunling;ZHANG Xiaogang;LI Yingdong(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Key Laboratory of TCM Prevention and Treatment of Chronic Diseases,Lanzhou 730000,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2024年第4期187-191,共5页
Chinese Journal of Information on Traditional Chinese Medicine
基金
甘肃中医药大学科学研究与创新基金(2021KCYB-5)
甘肃省教育科技创新项目-青年博士基金(2021QB-080)
甘肃省教育科技创新项目-教育揭榜挂帅项目(2021jyjbgs-03)
中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目(2018年)
甘肃省“双一流”科研重点项目(GSSYLXM-05)。
关键词
黄芪甲苷
心肌损伤
作用机制
综述
astragalosideⅣ
myocardial injury
mechanism
review
