从循证医学角度探讨妊娠期头颈部癌症的治疗策略

A perspective of evidence-based medicine on exploring the treatment strategy of head and neck cancer in pregnancy

虽然妊娠期合并恶性肿瘤较为罕见,但随着女性妊娠期年龄的增大、头颈部癌症(head and neck cancer,HNC)患者的年轻化,妊娠期合并HNC的发病率略有增加。然而,目前临床尚缺乏关于妊娠期HNC的规范化诊疗标准。本研究通过系统检索PubMed数据库,评估孕妇(含围产期)患HNC的频率、肿瘤类型、相关因素和特异性生物标志物,并依据循证医学证据,对妊娠期合并HNC的研究进行综述,以期为临床工作提供指导。

[Summary]The occurrence of malignant tumor during pregnancy is relatively rare,but with the increased age of pregnant women and the decreased age of patients suffering from head and neck cancer(HNC),the incidence of HNC complicated with pregnancy is slightly increasing.However,at present,there has been a lack of standardized diagnosis and treatment standards for pregnant woman with HNC.This paper evaluated the frequency,tumor type,associated factors,and specific biomarkers in HNCs occurring in pregnant women(including peripartum),based on systematic literature retrieval that performed on PubMed databank.From an evidence-based medicine view,this review presents a comprehensive description of the studies of pregnancy complicated with HNC,and intends to provide guidance in clinical practice.