特发性肺纤维化生物标志物研究进展

Research progress in biomarkers of idiopathic pulmonary fibrosis

特发性肺纤维化预后差、死亡率高,如果不及时治疗,中位生存期仅为2~3年。特发性肺纤维化患者早期症状不明显,确诊时往往是中后期,严重影响预后,因此,早诊断、早治疗尤为重要。生物标志物可以起到辅助诊断、评估病情和判断预后的作用。本研究根据特发性肺纤维化的发病机制从肺泡上皮细胞功能障碍、细胞外基质重塑和纤维增殖以及免疫功能障碍方面总结已发现的一些特发性肺纤维化生物标志物,希冀为特发性肺纤维化的早期诊断和治疗以及改善预后提供帮助。

Idiopathic pulmonary fibrosis has poor prognosis and high mortality,and if not treated in time,the median survival period is only 2~3 years after diagnosis.The early symptoms of idiopathic pulmonary fibrosis patients are not obvious,and the diagnosis is often in the mid to late stage of the disease,which seriously affects the prognosis.Therefore,early diagnosis and treatment are particularly important.Biomarkers can play a role in assisting diagnosis,evaluating the condition and predicting prognosis.The paper summarized some of the currently identified biomarkers of idiopathic pulmonary fibrosis from three aspects:alveolar epithelial cell dysfunction,extracellular matrix remodeling and fibrosis and immune dysfunction based on the pathogenesis of idiopathic pulmonary fibrosis,with the hope of providing assistance for the early diagnosis and treatment of idiopathic pulmonary fibrosis and improving prognosis.