1990—2019年全球异位妊娠疾病负担的区域分布与时间趋势

Regional distribution and temporal trends analysis of the global burden of ectopic pregnancy diseases from 1990 to 2019

目的:分析1990—2019年全球异位妊娠疾病负担的区域分布与时间趋势,为异位妊娠的防治提供参考。方法:使用2019年全球疾病负担研究数据,利用伤残调整生命年(disability-adjusted life years,DALYs)评价全球不同地区的异位妊娠负担变化。通过Spearman相关分析判断异位妊娠年龄标化DALYs率与社会人口指数(sociodemographic index,SDI)的关系。采用Joinpoint回归模型计算1990—2019年异位妊娠标化DALYs率的年度变化百分比和平均年度变化百分比(average annual percentage change,AAPC)。结果:1990—2019年全球异位妊娠年龄标化DALYs率下降了22.23%,从1990年的12.46/10万下降至2019年9.69/10万。非洲的异位妊娠标化DALYs率最高(2019年为42.77/10万)。2019年全球204个国家(不同SDI分区)的异位妊娠标化DALYs率与SDI呈负相关(r=-0.818,P<0.001)。Joinpoint回归分析显示,1990—2019年全球异位妊娠标化DALYs率呈下降趋势,AAPC为-0.93%。1990—2019年,不同SDI地区异位妊娠标化DALYs率均呈下降趋势,其中低SDI地区下降幅度最低(AAPC=-1.07%)。结论:1990—2019年全球异位妊娠疾病负担呈下降趋势,低SDI地区及非洲地区异位妊娠疾病负担较高。

Objective:To investigate the regional distribution and temporal trends of the global burden of ectopic pregnancy from 1990 to 2019,and provide reference for the prevention and treatment of ectopic pregnancy.Methods:Data from the Global Burden of Disease Study 2019 were used to evaluate changes in the burden of ectopic pregnancy in different regions of the world using disability-adjusted life years(DALYs).The relationship between the rate of age-standardized DALYs for ectopic pregnancy and sociodemographic index(SDI)was determined by Spearman correlation analysis.Joinpoint regression model was used to calculate the annual percentage change and average annual percentage change(AAPC)in the rate of standardized DALYs for ectopic pregnancy from 1990-2019.Results:The global rate of age-standardized DALYs for ectopic pregnancies decreased by 22.23%from 1990 to 2019,from 12.46/100,000 in 1990 to 9.69/100,000 in 2019.Africa had the highest rate of ectopic pregnancy age-standardized DALYs(42.77/100,000 in 2019).The global rate of ectopic pregnancy standardized DALYs in 204 countries(different SDI subregions)in 2019 was negatively correlated with SDI(r=-0.818,P<0.001).Joinpoint regression analysis showed that the global rate of ectopic pregnancy DALYs from 1990-2019 showed a decreasing with an AAPC of-0.93%.The rates of ectopic pregnancy standardized DALYs in different SDI regions showed a decreasing trend from 1990-2019,with the lowest decrease in low SDI regions(AAPC=-1.07%).Conclusion:The global disease burden of ectopic pregnancy showed a decreasing trend from 1990-2019,with higher disease burden of ectopic pregnancy in low SDI regions and in Africa.