血清MCP-1、hs-CRP及SIgA在急性盆腔炎的表达意义及其与疾病严重程度相关性分析

The Expression Significance of Serum MCP-1,hsCRP,and SIgA in Acute Pelvic Inflammatory Disease and Their Correlation with Disease Severity

目的探讨与分析血清分泌型免疫球蛋白A(sIgA)、单核细胞趋化蛋白-1(MCP-1)、超敏C-反应蛋白(hs-CRP)在急性盆腔炎(API)的表达意义及其与疾病严重程度的相关性。方法选择2021年7月—2023年5月在徐州市矿山医院诊治的79例急性盆腔炎患者作为盆腔炎组,选择同期在徐州市矿山医院体检的79名健康女性作为健康组,检测两组sIgA、MCP-1、hs-CRP含量,并对患者的疾病严重程度进行评分与相关性分析。结果两组年龄、身体质量指数、受教育年限、心率及空腹血糖等比较,差异无统计学意义(P>0.05),盆腔炎组血清sIgA、MCP-1、hs-CRP含量与健康组比较,差异有统计学意义(P<0.05);logistic回归分析显示,血清sIgA、MCP-1、hs-CRP含量为影响急性盆腔炎患者疾病的重要因素,差异有统计学意义(P<0.05);应用Spearman分析证明急性盆腔炎患者的疾病严重程度评分与血清sIgA含量存在负相关性,与单核细胞趋化蛋白-1、hs-CRP含量存在正相关性,差异有统计学意义(P<0.05)。结论急性盆腔炎患者的白带增多、腰骶胀痛的症状比较明显,多伴有血清单核细胞趋化蛋白-1、hs-CRP的高表达,也伴有血清sIgA的低表达,且与患者的疾病严重程度存在相关性。

Objective To investigate and analysis the expression of serum secretory immunoglobulin A(sIgA),Monocyte chemoattractant protein-1(MCP-1)and hypersensitive C-reactive protein(hs-CRP)in acute pelvic infl ammation(API)and their correlation with the severity of the disease. Methods From July 2021 to May 2023, 79 cases of patients with acute pelvic inflammatory disease diagnosed and treated in a hospital were selected as the pelvic inflammatory disease group, and the other 79 cases of healthy women were selected as the health group at the same time. The contents of sIgA, MCP- 1, and hs-CRP in the two groups were detected, and the disease severity of the patients were scored and analyzed. Results There was no diff erence in age, body mass index, years of education, heart rate, and fasting blood glucose between the two groups (P >0.05). The levels of serum monocyte chemoattractant protein-1, hypersensitive C-reactive protein, and secretory immunoglobulin A in the pelvic inflammatory disease group were significantly different from those in the healthy group (P <0.05);Logistic regression analysis showed that serum levels of secretory immunoglobulin A, monocyte chemotactic protein-1, and hypersensitive C-reactive protein were important factors affecting the disease in patients with acute pelvic infl ammatory disease (P<0.05);Spearman analysis was used to demonstrate a negative correlation between disease severity scores and serum secretory immunoglobulin A levels in patients with acute pelvic infl ammatory disease, and a positive correlation with monocyte chemotactic protein-1 and hypersensitive C-reactive protein levels (P< 0.05). Conclusion The patients with acute pelvic infl ammatory disease have a large amount of leucorrhea and obvious symptoms of lumbosacral distention and pain, which are often accompanied by high expression of serum Monocyte chemoattractant protein-1 and hypersensitive C-reactive protein, and also accompanied by low expression of serum secretory immunoglobulin A, and are related to the severity of the disease.