金属羰基化合物参与催化反应的研究进展

Research progress for the metal⁃carbonyl⁃compound involved catalytic reactions

在有机化学中,同时具备亲电中心和亲核中心的化合物一直是科研工作者的重点研究对象,而金属羰基化合物M-homoenolate(M为金属)在这类化合物中最具代表性,它可以作为一种碳亲核试剂与亲电试剂发生作用,实现羰基β位的碳碳键/碳杂键的偶联反应。由于羰基官能团广泛存在于醛类、酮类、酯类、酸酐类等化合物中,因此,对M-homoenolate的探索极具科学研究价值与市场应用价值;同时,它更是一类广泛应用于药物化学和天然分子合成中的中间体。

Compounds with both electrophilic and nucleophilic centers have always been a key research interest in organic chemistry.As the most representative compound of this kind,M⁃homoenolate,functioning as a carbon nucleophilic reagent reacting with electrophilic reagent,facilitates the coupling reactions of carbon⁃carbon bonds and carbon⁃hetero bonds atβ⁃position of carbonyl groups.The ubiquity of carbonyl functional groups in compounds including aldehydes,ketones,esters,and anhydrides underscores the scientific and market values of exploring M⁃homoenolate.Additionally,it is also an intermediate widely used in pharmaceutical chemistry and the synthesis of natural molecules.