奥美拉唑联合康复新液治疗多源性消化道出血的效果

Effect of Omeprazole Combined with Kangfuxin Solution in the Treatment of Multi-source Gastrointestinal Bleeding

目的:探讨奥美拉唑联合康复新液治疗多源性消化道出血的临床效果,并评估其对血清炎性因子水平的影响。方法:选取2022年1-10月南京市溧水区中医院收治的消化道出血患者76例作为研究对象,随机数字表法分为对照组和观察组,各38例。对照组给予奥美拉唑治疗,观察组在对照组基础上给予康复新液治疗。比较两组愈合情况,凝血指标[血小板计数(PLT)、纤维蛋白原(FBG)、凝血酶原时间(PT)及部分活化凝血酶原时间(APPT)],炎性因子[白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]。结果:观察组治愈率及总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,两组PLT及FBG水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组APPT及PT低于治疗前,观察组APPT低于对照组,差异有统计学意义(P<0.05)。治疗后,两组IL-6与TNF-α水平均低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。结论:奥美拉唑联合康复新液治疗多源性消化道出血的效果显著,能有效降低血清炎性因子水平,改善凝血指标,为减少消化道出血相关并发症提供新的治疗策略。

Objective:To investigate the clinical effect of omeprazole combined with Kangfuxin solution in the treatment of multi-source gastrointestinal bleeding,and to evaluate the effect of omeprazole on serum inflammatory factors.Methods:A total of seventy-six patients with gastrointestinal hemorrhage admitted to Nanjing Lishui District Hospital of Traditional Chinese Medicine from January 2022 to October 2022 were selected as the study objects,and were divided into control group and observation group by random number table method,with thirty-eight cases in each group.The control group was treated with omeprazole,and the observation group was treated with Kangfuxin solution on the basis of the control group.The healing,coagulation indexes[platelet count(PLT),fibrinogen(FBG),prothrombin time(PT)and partially activated prothrombin time(APPT)],inflammatory factors[interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]were compared between the two groups.Results:The cure rate and total effective rate of the observation group were higher than those of the control group,the difference was statistically significant(P<0.05);after treatment,PLT and FBG levels in two groups were higher than before treatment,and observation group was higher than control group,the difference was statistically significant(P<0.05);after treatment,APPT and PT in the two groups were shorter than before treatment,and APPT in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05);after treatment,the levels of IL-6 and TNF-αin both groups were lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.05).Conclusion:Omeprazole combined with Kangfuxin solution can effectively reduce the level of serum inflammatory factors,improve coagulation indexes,and provide a new treatment strategy for reducing complications related to gastrointestinal bleeding.