吸入用布地奈德混悬液联合常规药物治疗小儿支气管哮喘急性发作的临床效果

Clinical Effect of Inhaled Budesonide Suspension Combined with Conventional Drugs in the Treatment of Acute Attack of Bronchial Asthma in Children

目的:探究吸入用布地奈德混悬液联合常规药物治疗小儿支气管哮喘急性发作的临床效果。方法:选取2023年1-9月于遵义市妇幼保健院收治的小儿支气管哮喘急性发作患儿62例作为研究对象,以单双数法随机分为研究组和对照组,各31例。对照组实施常规药物治疗,研究组在对照组基础上采用吸入用布地奈德混悬液治疗。比较两组临床治疗效果、症状缓解时间、动脉血气分析指标、肺功能指标以及药物不良反应发生情况。结果:研究组总有效率高于对照组,差异有统计学意义(P<0.05);研究组咳嗽、哮鸣音、憋喘、呼吸困难缓解时间均短于对照组,差异有统计学意义(P<0.05);治疗前,两组血气指标比较,差异无统计学意义(P>0.05);治疗后,研究组酸碱度、动脉血氧分压水平高于对照组,动脉血二氧化碳分压水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组肺功能指标比较,差异无统计学意义(P>0.05);治疗后,研究组用力肺活量(FVC)、第1秒用力呼气容积(FEV1)及FEV1/FVC水平均高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:针对支气管哮喘急性发作期患儿,应用常规药物联合吸入用布地奈德混悬液治疗的效果显著,能够有效缓解患儿临床症状,改善血气指标的同时提升肺功能,且不良反应发生率较低,值得临床推广。

Objective:To explore the clinical effect of inhaled budesonide suspension combined with conventional drugs in the treatment of acute attack of bronchial asthma in children.Methods:A total of sixty-two children with bronchial asthma who received acute attack treatment in Zunyi Maternal and Child Health Hospital from January 2023 to September 2023 were selected as the research objects,and randomly divided into the study group and the control group by singled-even number method,with thirty-one cases in each group.The control group received conventional drug treatment,and the study group received inhaled budesonide suspension on the basis of the control group.The clinical therapeutic effect,symptom remission time,arterial blood gas analysis index,pulmonary function index and the occurrence of adverse drug reactions were compared between the two groups.Results:The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05);the remission time of cough,wheezing,breathless and dyspnea in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05);before treatment,there was no significant difference in blood gas indexes between the two groups(P>0.05);after treatment,the pH and partial pressure of arterial blood oxygen in the study group were higher than those in the control group,and the partial pressure of arterial blood carbon dioxide was lower than those in the control group,with statistical significance(P<0.05);before treatment,there was no significant difference in lung function indexes between the two groups(P>0.05);after treatment,the levels of forced vital capacity(FVC),forced expiratory volume at the first second(FEV1)and FEV1/FVC in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05);there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:For children with acute attacks of bronchial asthma,the treatment of conventional drugs combined with inhaled budesonide suspension has a significant effect,which can effectively alleviate clinical symptoms of children,improve blood gas indexes and enhance lung function of children,and the incidence of adverse reactions is low,which is worthy of clinical promotion.