基于肠道菌群代谢和免疫炎症分析中药缓解抑郁症的研究现状

Traditional Chinese medicine alleviates depression based on immune inflammation and intestinal flora metabolism

抑郁症是以连续而长期的心情低落为主要临床特征的一类最常见的精神疾病。肠道菌群的变化可导致肠道炎症,进而影响外周与中枢神经系统炎症。现代研究表明抑郁症的发生发展与肠道菌群的改变密切相关,肠道菌群已成为缓解抑郁症的关键靶点。在一定程度上中药能够调节肠道菌群及其代谢产物,修复肠道屏障,降低全身炎症水平,从而缓解抑郁症。本综述以肠道菌群为切入点,通过分析肠道菌群的代谢、免疫炎症与抑郁症发生发展的关系以及中药在调节肠道菌群缓解抑郁症方面的研究,总结中药通过影响肠道菌群的代谢,降低炎症水平,缓解抑郁症的作用和机制,以期为中药缓解抑郁症及相关药物的研发提供新思路。

Depression is one of the most common mental diseases with continuous and long-term depression as the main clinical features.The change in intestinal flora can lead to intestinal inflammation,and then affects inflammation in peripheral and central nervous system.Modern studies have shown that the occurrence and development of depression are closely related to the change of intestinal flora,which has become a key target for alleviating depression.To a certain extent,traditional Chinese medicine(TCM)can regulate intestinal flora and its metabolites,which repairs the intestinal barrier and reduces inflammation level throughout the whole body to alleviate depression.With intestinal flora as an entry point,by analyzing the relationship of intestinal flora and immune inflammation with the occurrence and development of depression,as well as the researches on TCM in alleviating depression and regulating intestinal flora,this article summarizes the effects and mechanisms of TCM in reducing inflammation and alleviating depression by regulating intestinal flora,in order to provide new ideas for alleviating depression with TCM and the drug development.