慢性自发性荨麻疹与肠道菌群的关系

The advances of the relationship between chronic spontaneous urticarial and gut flora

慢性自发性荨麻疹(Chronic spontaneous urticaria,CSU)是皮肤科常见的慢性炎症性疾病,其发病机制至今尚无定论。肠道菌群是人体最大的微生态系统,在免疫系统的调节和发展中起重要作用。研究表明,CSU患者体内存在肠道菌群生物多样性的减少和组成紊乱,主要表现为厚壁菌和拟杆菌等有益菌的减少,变形杆菌等条件致病菌的增多,肠道菌群参与CSU发病机制可能与其代谢产物短链脂肪酸的作用有关。本文综述了CSU患者肠道菌群的组成变化以及肠道菌群参与CSU可能的病理机制,为基于肠道菌群的CSU治疗提供参考。

Chronic spontaneous urticaria(CSU)is a common chronic inflammatory disease in dermatology,but its pathogenesis is still inconclusive.The gut flora is the largest micro-ecological system in the human body,and it has a major impact on the regulation and development of the immune system.Recent studies have shown that there is a decrease in gut flora biodiversity and composition disorder in CSU patients.The main manifestation is the reduction of beneficial bacteria such as firmicutes and bacteroides,The increase of opportunistic pathogens such as proteus,the involvement of gut flora in the pathogenesis of CSU may be related to the role of its metabolic product short-chain fatty acids This article reviews the relationship between CSU and gut flora,summarizes the possible pathological mechanism and the composition changes of gut flora in CSU patients,trying to provides theoretical and literature reference for CSU treatment based on gut flora.