基于动而生阳理论的八段锦运动训练对老年恶性肿瘤患者化疗期衰弱水平、抑郁状况及炎症介质的影响

To explore the influence of Baduanjin method based on the theory of“Producing Yang by moving”on frailty,depression and inflammatory mediators during chemotherapy in elderly patients with malignant tumors

目的:探讨基于动而生阳理论制定的八段锦运动训练对老年恶性肿瘤患者化疗期衰弱水平、抑郁状况及炎症介质的影响。方法:采用便利抽样法,选取广东省某三甲医院肿瘤科2022年1月至12月收治的81位老年恶性肿瘤化疗患者为研究对象,并采用随机数字法,将81名老年恶性肿瘤化疗患者简单随机分成两组,其中对照组41例和干预组40例,对照组维持既往的日常活动状态,干预组在对照组基础上进行12周的八段锦集中训练。研究人员分别在八段锦运动干预前、干预第六周强化练习结束后、干预第十二周强化练习结束后比较干预两组患者衰弱水平(FP)及抑郁状况(SDS评分),炎症介质(C反应蛋白)的变化。结果:共纳入81例患者。在进行八段锦6周运动干预后,干预组与对照组两组患者衰弱水平差异无统计学意义(P>0.05),但在12周八段锦运动训练后,干预组衰弱水平显著下降,两组衰弱水平差异有统计学意义(P<0.05);干预组患者在6周和12周八段锦运动训练中,其抑郁状况持续下降,与对照组差异抑郁状况均有统计学意义(P<0.05);干预组患者炎症介质水平在八段锦运动训练第6周和第12周运动干预后,其炎症介质水平与对照组相比均较低,差异均有统计学意义(P<0.05)。结论:八段锦对于老年恶性肿瘤患者化疗期衰弱水平、抑郁状况、炎症指标水平均有所改善,可在老年恶性肿瘤患者化疗期进行推广习练。

Objective:To explore the influence of Baduanjin method based on the theory of“Producing Yang by moving”on frailty,depression and inflammatory mediators during chemotherapy in elderly patients with malignant tumors.Methods:using convenience sampling,To select 81 cases of elderly patients with malignant tumors admitted to Department of Oncology,a tertiary hospital in Guangdong Province,from January 2022 to December 2022.And using the random number method,Eighty-one elderly chemotherapy patients with malignancy were simply randomly divided into two groups,Among them,41 cases were in the control group and 40 cases in the intervention group,The control group maintained its previous daily activities,The intervention group underwent 12 weeks of Baduanjin intensive training on the basis of the control group.The researchers compared the changes of frailty level(FP),depression status(SDS score),and inflammatory mediator(C-reactive protein)between the two groups before the Baduanjin exercise intervention,after the sixth week of the intervention and after the end of the twelfth week of the intervention.Results:A total of 81 patients were included.After 6 weeks of the Baduanjin intervention,There was no significant difference in the level of frailty between the intervention group and the control group(P>0.05),However,after 12 weeks of aduanjin training,the level of frailty in the intervention group decreased significantly,There was a significant difference in the level of frailty between the two groups(P<0.05);In the intervention group,the depression of the patients in the intervention group continued to decrease during the 6 weeks and 12 weeks of Baduanjin exercise,and the difference in depression was statistically significant compared with the control group(P<0.05);After the exercise intervention at week 6 and week 12 of Baduanjin training,the levels of inflammatory mediators in the intervention group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Baduanjin can improve the level of frailty,depression and inflammation indicators in elderly patients with malignant tumors during chemotherapy,and can be promoted and practiced in elderly patients with malignant tumors during chemotherapy.