乳腺癌患者血清CEA、AFp、CA125联合检测的临床意义及应用价值分析

Clinical Significance and Application Value of combined Detection of serum CEA, AFP and CA125 in Patients with Breast Cancer

目的分析乳腺癌患者血清癌胚抗原(CEA)、甲胎蛋白(AFp)、糖类抗原125(CA125)联合检测的临床意义及应用价值。方法在漯河市舞阳县人民医院选取27例乳腺癌患者作为试验A组研究对象,选取28例良性乳腺疾病患者作为试验B组研究对象,再选取27例参与健康体检的女性作为对照组研究对象。采用分层整群抽样法纳入样本,纳入时间为2020年6月至2023年6月。对比三组研究对象的CEA、AFp、CA125检查结果。对比各检测指标单项检测与三项联合检测诊断特异度、敏感度、准确度。结果试验A组CEA、AFp、CA125水平高于试验B组、对照组,差异具有统计学意义(P<0.05);金标准(病理检查)检查发现阳性27例,阴性55例;CEA检查诊断阳性20例,阴性62例;AFp检查诊断阳性18例,阴性64例;CA125检查诊断阳性21例,阴性61例,联合检查诊断阳性26例,阴性56例;三项指标联合诊断准确度、灵敏度及特异度(96.34%、92.59%、98.18%)相较于单独CEA检查(71.95%、44.44%、85.45%)、单独AFp检查(71.95%、40.74%、87.27%)、单独CA125检查(73.17%、48.15%、85.45%)高,差异具有统计学意义(P<0.05)。结论联合检测血清CEA、AFp、CA125可用于乳腺癌诊断,值得应用。

Objective To analyze the clinical significance and application value of combined detection of serum carcinoembryonic antigen(CEA),alpha fetoprotein(AFP)and carbohydrate antigen 125(CA125)in patients with breast cancer.Methods A total of 27 patients with breast cancer were selected as study subjects in group A,28 patients with benign breast disease were selected as study subjects in group B,and 27 women who participated in physical examination were selected as control subjects in Wuyang People's Hospital of Luohe City.The sample was included using stratified cluster sampling method from June 2020 to June 2023.The CEA,AFP,and CA125 test results of three study groups were compared.The diagnostic specificity,sensitivity,and accuracy of individual testing and three joint testing for each detection indicator were compared.Results The levels of CEA,AFP,and CA125 in group A were higher than those in group B and the control group,and the differences were statistically significant(P<0.05);The gold standard(pathological examination)examination found 27 positive cases and 55 negative cases;20 cases were diagnosed positive and 62 cases were negative by CEA examination;18 cases were diagnosed positive and 64 cases were diagnosed negative by AFP examination;21 cases were positive and 61 cases were negative in CA125 examination,26 cases were positive and 56 cases were negative in combined examination;The combined diagnostic accuracy,sensitivity,and specificity of the three indicators(96.34%,92.59%,98.18%)were higher than those of CEA alone(71.95%,44.44%,85.45%),AFP alone(71.95%,40.74%,87.27%),and CA125 alone(73.17%,48.15%,85.45%),and the differences were statistically significant(P<0.05).Conclusion The combined detection of serum CEA,AFP and CA125 can be used for the diagnosis of breast cancer and is worth applying.