六项呼吸道病原体IgM抗体检测在呼吸道感染中的价值研究

Study on the Value of Six Respiratory Pathogen IgM Antibody Tests in Respiratory Infections

目的分析六项呼吸道病原体[肺炎衣原体(CPN);肺炎支原体(MP);呼吸道合胞病毒(RSV);腺病毒(ADV);乙型流感病毒(IBV);副流感病毒(PIV)]血清免疫球蛋白M(IgM)抗体检测在呼吸道感染中的应用价值。方法选取禹州市中医院在2023年1月至2023年11月期间收治的76例呼吸道感染患者(感染组)与同期进行健康体检的76名健康体检者(健康组)作为本次研究对象,采用间接荧光免疫法对所有研究对象的血清进行呼吸道病原体IgM抗体检测,分析两组研究对象病原体IgM检测结果以及不同年龄、季节下机体病原体感染情况。结果感染组六项呼吸道病原体IgM抗体阳性率较健康组高,差异具有统计学意义(P<0.05),其中,不同病原体感染率相比,MP感染率(36.84%)最高。单一感染较混合感染发生率高,其中,在混合感染中MP+IV感染多见,差异具有统计学意义(P<0.05)。从年龄阶段来看,<18岁群体中以PIV感染为主,差异具有统计学意义(P<0.05)。从季节来看,MP、PIV在夏、秋季检出率较高,RSV在冬春季检出率较高,差异具有统计学意义(P<0.05),其他病原体感染在不同季节差异无统计学意义(P>0.05)。结论呼吸道感染患者中以MP感染为主,在不同年龄阶段与季节中,其病原体感染情况不同,六项呼吸道病原体抗体联合检测可提高呼吸道病原体的阳性检出率,故可将六项呼吸道病原体IgM抗体联合检测应用到呼吸道感染性疾病的诊断中,快速明确感染病原体的类别,为临床后续治疗提供参考依据。

Objective To analyze the application value of six respiratory pathogen[Chlamydia pneumoniae(CPN);Mycoplasma pneumoniae(MP);Respiratory syncytial virus(RSV);Adenovirus(ADV);Influenza B virus(IBV);Parainfluenza virus(PIV)]serum immunoglobulin M(IgM)antibody tests in respiratory infections.Methods 76 patients with respiratory infections who were admitted to Yuzhou City Hospital from January 2023 to November 2023(infection group)and 76 healthy examinees who underwent health examinations during the same period(healthy group)were selected as the research objects of this study.The serum of all research objects was tested for respiratory pathogen IgM antibodies using indirect immunofluorescence,and the results of pathogen IgM tests in the two groups of research objects and the infection of pathogens in the body under different ages and seasons were analyzed.Results The positive rate of IgM antibodies to six respiratory pathogens in the infection group was higher than that in the healthy group,and the difference was statistically significant(P<0.05).Among them,compared with the infection rate of different pathogens,the infection rate of MP(36.84%)was the highest.Single infections had a higher incidence than mixed infections.Among them,MP+IV infections were common in mixed infections,and the difference was statistically significant(P<0.05).From the perspective of age stages,PIV infection is the main infection in the group under 18 years old,and the difference is statistically significant(P<0.05).From the perspective of seasons,the detection rates of MP and PIV are higher in summer and autumn,and the detection rate of RSV is higher in winter and spring,and the difference is statistically significant(P<0.05).The difference in the infection of other pathogens in different seasons is not statistically significant(P>0.05).Conclusion Among patients with respiratory infections,MP infection is the main one.In different age stages and seasons,the infection of pathogens is different.The combined detection of antibodies to six respiratory pathogens can increase the positive detection rate of respiratory pathogens.Therefore,the combined detection of IgM antibodies to six respiratory pathogens can be applied to the diagnosis of respiratory infectious diseases,quickly clarify the category of infection pathogens,and provide a reference for subsequent clinical treatment.