壳聚糖温敏水凝胶在口腔相关组织工程的应用进展

Application advances of chitosan thermosensitive hydrogels in oral-related tissue engineering

壳聚糖是一种通过甲壳素脱乙酰化衍生而来的天然高分子多糖。脱乙酰基后,壳聚糖可以很容易地与DNA、蛋白质、脂类或带负电的合成聚合物产生相互作用,从而拥有独特的生物相容性、降解性等特性。壳聚糖温敏性水凝胶是由壳聚糖与表面活性剂复合制成的高分子水凝胶,当外界温度发生变化时,水凝胶自身发生状态的变化。因温敏性水凝胶具有良好的生物相容性、较低组织免疫反应及优良的细胞黏附性,在组织工程技术、药物载体、再生医学等方面有着重要应用价值。本文将对壳聚糖及壳聚糖温敏性水凝胶对口腔组织工程中的应用进行简要综述。

Chitosan is a natural polymeric polysaccharide derived through deacetylation of chitin.After deacetylation,chitosan can easily interact with DNA,proteins,lipids or negatively charged synthetic polymers,thus possessing unique biocompatibility,degradability and other properties.Chitosan thermosensitive hydrogels are polymeric hydrogels made of chitosan compounded with surfactants,and the hydrogels themselves undergo state changes when the external temperature changes.Because of the good biocompatibility,low tissue immune response and excellent cell adhesion,thermosensitive hydrogels have important applications in tissue engineering,drug carriers and regenerative medicine.In this paper,the applications of chitosan and chitosan thermosensitive hydrogels in oral tissue engineering will be briefly reviewed.