牙龈卟啉单胞菌在非酒精性脂肪肝病进展中的作用

The role of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease

以牙龈卟啉单胞菌为代表的牙周致病菌不仅危害口腔健康,还与非酒精性脂肪肝病等口腔外疾病有着重要联系。牙龈卟啉单胞菌及其产物可通过血行途径和肠道途径等多种途径促进非酒精性脂肪肝病的发展,本文就相关作用途径及可能机制作一综述。

Porphyromonas gingivalis(P.gingivalis),a key pathogen of periodontitis,not only harms oral health,but also has an important relationship with the development of many extraoral diseases,such as non-alcoholic fatty liver disease.P.gingivalis and its products can promote the development of non-alcoholic fatty liver disease through hematogenous and intestinal pathways.In this paper,the pathway and possible internal mechanisms involved are briefly described.