阻塞性睡眠呼吸暂停综合征患者中肌少症患病率的meta分析

A meta-analysis of the prevalence of sarcopenia in patients with obstructive sleep apnea syndrome

目的分析阻塞性睡眠呼吸暂停综合征(OSAS)患者中肌少症的患病率,增强大众防病意识,做好肌少症防治。方法检索CNKI、万方、PubMed、Web of Science和Cochrane等数据库,搜集关于OSAS与肌少症的相关研究,时间范围为1994年—2023年1月28日。由2位研究者独立筛选文献、提取数据并评价纳入研究的质量,采用Stata 16统计学软件进行meta分析。结果共纳入9项研究,收集样本量合计2815例,其中肌少症患者362例。Meta分析结果显示:OSAS患者中肌少症患病率为31.58%(95%CI:18.65%~44.50%)。以OSAS严重程度分组,中重度OSAS的肌少症患病率为43.81%(95%CI:12.66%~74.95%),而轻中重度人群相应患病率为28.17%(95%CI:13.80%~42.54%);不同年龄组间比较,40~60岁患者中肌少症患病率为17.89%(95%CI:8.15%~27.62%),≥60岁老年患者的患病率明显升高[50.86%(95%CI:42.46%~59.25%)]。结论OSAS患者中肌少症患病率较高,且在老年亚组中肌少症高发。做好肌少症防治,同时要重视对睡眠障碍的筛查与治疗。

Objective To investigate the prevalence of sarcopenia in patients with obstructive sleep apnea syndrome(OSAS),to improve the awareness of the disease and aid in its prevention and treatment.Methods Relevant studies on OSAS and sarcopenia in patients were searched in the CNKI,Wanfang,PubMed,Web of Science and Cochrane databases from 1994 to January 28,2023.Two researchers independently screened the literature,extracted data,and evaluated the quality of the included studies.Meta-analysis was performed using Stata 16.Results The analysis comprised nine studies,with a total of 2815 patients diagnosed with OSAS,among whom 362 were diagnosed with sarcopenia.The metaanalysis revealed that the prevalence of sarcopenia in patients with OSAS was 31.58%(95%CI:18.65%-44.50%).The prevalence of sarcopenia in moderate to severe OSAS was 43.81%(95%CI:12.66%-74.95%),while the corresponding prevalence in mild to moderate to severe OSAS was 28.17%(95%CI:13.80%-42.54%).A subgroup analysis based on age revealed that the prevalence of sarcopenia was 17.89%(95%CI:8.15%-27.62%)in patients aged 40-60 years.The prevalence significantly increased in patients aged≥60 years to 50.86%(95%CI:42.46%-59.25%).Conclusion The prevalence of sarcopenia was high in patients with OSAS,and this varied across different age groups.The prevalence of sarcopenia was higher in elderly patients aged 60 years or older.To effectively prevent and treat sarcopenia,it is important to focus on screening and treating sleep disorders.This will require increased attention to be paid to identifying and addressing sleep-related issues.