丝裂霉素C联合尿道内切开术治疗尿道狭窄的研究进展

Research progress of mitomycin C combined with internal urethrotomy in the treatment of urethral stricture

直视下尿道内切开术是目前治疗尿道狭窄的主要方式之一。由于术后瘢痕形成,狭窄复发率较高,多数患者需重复多次手术。丝裂霉素C可以通过抑制成纤维细胞的增殖,减少肉芽组织和瘢痕形成。有研究发现,丝裂霉素C联合尿道内切开术可以明显降低尿道狭窄的复发率。本文通过系统性文献回顾,对丝裂霉素C联合尿道内切开术的用药方式、安全性、有效性和局限性进行总结,以期为临床应用提供参考。

Direct vision urethral incision is currently one of the main methods for treating urethral stricture.Due to postoperative scar formation,the recurrence rate of stricture is high,and most patients need to repeat multiple surgeries.Mitomycin C can reduce granulation tissue and scar formation by inhibiting fibroblast proliferation.Studies have found mitomycin combined with internal urethrotomy for urethral stricture can greatly reduce the recurrence rate of treating urethral stricture.This article summarizes the medication,safety,efficacy,and limitations of internal urethrotomy combined with mitomycin C through a systematic literature review,to provide reference for clinical practice.