清咳平喘颗粒联合阿莫西林治疗成人急性支气管炎的临床研究

Clinical study of Qingke Pingchuan Granules combined with amoxicillin in treatment of adult patients with acute bronchitis

目的 探讨中成药清咳平喘颗粒联合阿莫西林治疗成人急性支气管炎的临床疗效。方法 选取2022年3月—2023年1月宿迁市中医院收治的93例急性支气管炎患者为研究对象,根据治疗方法不同分为对照组(n=45)和试验组(n=48)。对照组患者给予阿莫西林胶囊,每次0.5 g,每天3次。试验组在对照组的基础上加用清咳平喘颗粒,每次10 g,每天3次。两组均连续治疗7 d,观察两组患者治疗前后临床疗效、中医证候积分、临床症状消失时间、简易咳嗽程度评分表(CET)评分、血清炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)]水平,并进行组间差异比较。结果 试验组总有效率(97.92%)显著高于对照组(87.67%)(P<0.05)。两组均能降低中医证候积分(咳嗽、咳痰、痰鸣音、喘息)、缩短临床症状(咳嗽、咳痰、喘息)消失时间(P<0.05),显著降低咳嗽程度CET评分及血清IL-6、TNF-α、hs-CRP、PCT水平(P<0.05),且试验组效果均显著优于对照组(P<0.05)。结论 清咳平喘颗粒联合阿莫西林治疗急性支气管炎疗效确切,能显著提高临床有效率,改善患者临床症状,缩短患者病程,改善炎症反应,具有临床推广应用价值。

Objective To explore the clinical efficacy of Chinese patent medicine Qingke Pingchuan Granules combined with amoxicillin in treatment of adult patients with acute bronchitis.Methods A total of 93 patients with acute bronchitis treated in Suqian Traditional Chinese Medicine Hospital from March 2022 to January 2023 were divided into control group(n = 45) and experimental group(n = 48).Patients in the control group were given Amoxicillin Capsule,0.5 g once time,three times once day.On the basis of the control group,patients in the experimental group were added with Qingke Pingchuan Granules,10 g once time,three times once day.All patients were treated for seven days.The clinical efficacy,TCM syndrome score,clinical symptom disappearance time,cough degree score,serum inflammatory factor level before and after treatment of the two groups were observed,and the differences between the two groups were compared.Results The total effective rate of the experimental group(97.92%) was significantly higher than that of the control group(87.67%)(P < 0.05).Traditional Chinese medicine syndrome scores(cough,expectoration,phlegm sounds,and wheezing) of patients in two groups were reduced,the disappearance time of clinical symptoms(cough,expectoration,and wheezing) were shortened(P < 0.05),cough severity CET scores and serum inflammatory factor levels [interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high sensitivity C-reactive protein(hs-CRP),calcitonin(PCT)]were reduced significantly(P < 0.05),and effect of the experimental group was significantly stronger than the control group(P <0.05).In addition,the TCM syndrome score of wheezing in the experimental group was significantly improved(P < 0.05).Conclusion Qingke Pingchuan Granules combined with amoxicillin is effective in treatment of acute bronchitis.It can significantly improve the clinical effective rate,improve the clinical symptoms,shorten the course of the disease,improve the inflammatory response,and has the value of clinical application.