纳米氧化锌抗血液肿瘤的药理作用及机制研究进展

Research progress on pharmacological action and mechanism of nano-zinc oxide against hematological tumors

纳米氧化锌(ZnO-NPs)是直径在1~100 nm的无机材料,具有靶向肿瘤细胞、对血液肿瘤细胞敏感的特性,而对正常细胞影响较小,在治疗血液肿瘤方面逐渐成为研究热点。ZnO-NPs通过阻滞细胞周期、抑制肿瘤细胞增殖、调控线粒体功能、通过释放Zn^(2+)来影响细胞稳态等进而诱导肿瘤细胞凋亡,从而破坏肿瘤细胞稳态;还可增敏化疗药物,并作为生物传感器,在治疗血液肿瘤方面具有很大潜力。对ZnO-NPs的药理作用及其在抗白血病、多发性骨髓瘤、淋巴瘤中的药理机制进行综述,以期为优化血液肿瘤治疗手段提供新策略。

Nano-zinc oxide(ZnO-NPs) is an inorganic material with a diameter of 1-100 nm,which has the characteristics of targeting tumor cells and being sensitive to blood tumor cells,but has little influence on normal cells,and has gradually become a research hotspot in the treatment of blood tumors.ZnO-NPs induces apoptosis by blocking cell cycle,inhibiting the proliferation of tumor cells,regulating mitochondrial function,and releasing Zn(2+) to affect cell homeostasis,thus destroying the homeostasis of blood tumor cells.It can sensitize chemotherapy drugs and can be used as a biosensor,which has great potential in the treatment of blood tumors.The pharmacological effects of ZnO-NPs and its mechanism in leukemia,multiple myeloma and lymphoma were reviewed in order to provide new strategies for optimizing treatment methods.