阴道微生态与宫颈HR-HPV感染及宫颈病变关系的研究进展

Research progress on the relationship between vaginal microecology and cervical HR-HPV infection and cervical lesions

高危型人乳头瘤病毒(HR-HPV)感染是导致宫颈上皮瘤变(CIN)及宫颈癌的关键因素。阴道内环境在正常情况下由于各菌群的动态平衡而处于稳定状态,由此构成女性生殖系统健康的重要基础,其中乳酸杆菌为优势菌群,在各种致病因素的作用下,各菌群间此消彼长,平衡状态由此被打破,导致阴道炎症病发率和HR-HPV感染率上升,并引发一系列宫颈病变,如无有效预防及干预手段,将进一步发展为宫颈癌。本文综述阴道微生态与宫颈HR-HPV感染及宫颈病变的关系的最新研究成果,以期为临床降低HR-HPV感染率及干预宫颈病变提供一定借鉴。

High-risk human papillomavirus(HR-HPV)infection is a key factor leading to cervical intraepithelial neoplasia(CIN)and cervical cancer.Under norm al circumstances,the vaginal internal environm ent is in a stable state due to the dynamic balance of various bacterial communities,constituting an important foundation for the health of the female reproductive system.Among them,lactobacillus is the dominant bacterial community.Under the influence of various pathogenic factors,the balance between these bacterial communities is disrupted due to the shift in bacterial communities,leading to broken balance and an increase in the incidence of vaginitis and HR-HPV infection,as well as a series of cervical lesions.Without effective prevention and intervention measures,they will further develop into cervical cancer.This article reviews the latest research results on the relationship between vaginal microecology and cervical HR-HPV infection and cervical lesions,to provide some reference for clinical reduction of HR-HPV infecti on rate and intervention in cervical lesions.