基于“心脑一体观”探讨针灸调节褪黑素的作用机理

Discussion on the mechanism of action of acupuncture and moxibustion in regulating melatonin based on the"heart-brain integration view"

现代医学认为,脑主导机体的一切生命过程和精神活动,且与周围环境的平衡和调节存在关系。而中医认为“心者,君主之官,神明出焉”,心有主宰身体和神志的功能。褪黑素(MT)是脑室内松果体分泌的一种激素,其在人体的效应有类似中医理论中的“心”“神”作用。如何理解并且融通中医和现代医学两个不同的理论体系,是目前在临床和科研中的重要问题。“心脑一体观”是结合不同理论体系的对同一个生理现象的探讨。本研究基于“心脑一体观”探讨MT失调所致疾病的相关研究,阐释针灸通过调理“心”“神”相关的穴位组合,不仅可改善失眠、抑郁、肥胖、血管性痴呆、胃溃疡等疾病症状,同时具有调节MT水平的作用,为临床针灸治疗MT相关疾病的腧穴配伍提供理论依据。

Modern medicine believes that the brain dominates all life processes and mental activities of the body,and is related to the balance and regulation of the surrounding environment.Traditional Chinese medicine believes that"the heart is the organ similar to the monarch and is responsible for spirit and mental activity".The heart has the function of controlling the body and mind.Melatonin(MT)is a hormone secreted by the pineal gland in the ventricles of the brain,and its effects on the human body are similar to those of the"heart"and"spirit"in traditional Chinese medicine theory.How to understand and integrate the two different theoretical systems of traditional Chinese medicine and modern medicine is an important issue in our current clinical and scientific researches.The"heart-brain integration view"is a discussion of the same physiological phenomenon that combines different theoretical systems.Based on the"heart-brain integration view",this study explores the related research on diseases caused by melatonin imbalance and explains that acupuncture and moxibustion can not only improve the symptoms of insomnia,depression,obesity,vascular dementia,gastric ulcer and other diseases by regulating the combination of acupoints related to"heart"and"spirit",but also regulate the level of melatonin,providing a theoretical basis for the acupoint compatibility of acupuncture and moxibustion in treating melatonin related diseases in clinical practice.