METTL16在肿瘤中的研究进展

Research progress of METTL16 in tumors

甲基转移酶16(METTL16)是一种新发现的N6-甲基腺苷(m^(6)A)甲基转移酶,其在肿瘤研究中的作用日益突显,已被证实在多种肿瘤疾病中异常表达,且发挥着不同程度的调控作用。METTL16可通过发挥甲基转移酶的活性调控目标RNA的稳定性,进而通过影响细胞周期转变、促进糖酵解、抑制铁死亡等方式在不同肿瘤中发挥促癌或抑癌作用。然而,亦有报道METTL16可以通过与真核翻译起始因子相互作用促进翻译,以不依赖其甲基转移酶活性的方式,促进肿瘤的发生发展。因此,METTL16在肿瘤疾病的研究中具有重要的价值,有望成为肿瘤早期诊断和治疗的一种新的生物标志物。本文重点介绍METTL16在肿瘤发生发展中作用的研究进展。

Methyltransferase 16(METTL16)is a newly discovered N6-methyladenosine(m^(6)A)methyltransferase,which plays an increasingly prominent role in tumor research and has been confirmed to be abnormally expressed in various tumor diseases,playing varying degrees of regulatory roles.METTL16 can regulate the stability of target RNA by exerting the activity of methyltransferase,thereby exerting tumor-promoting or inhibiting effects in different tumors by influencing cell cycle transition,promoting glycolysis and inhibiting ferroptosis.However,there are also reports that METTL16 can promote translation by interacting with eukaryotic translation initiation factors,and promote the occurrence and development of tumors without relying on its methyltransferase activity.Therefore,METTL16 holds important value in the research of tumor diseases,and it is expected to become a new biomarker for early diagnosis and treatment of tumors.This review focuses on the research progress of METTL16 in the occurrence and development of tumors.