火把花根片治疗慢性肾病的效果

Effect of Huobahuagen Tablets on chronic kidney disease

目的研究火把花根片治疗慢性肾病的效果及对患者尿蛋白、肝肾功能及血脂等的影响。方法采用回顾性队列研究对2022年6月—2023年4月于我院门诊诊治的100例慢性肾病患者的资料进行分析,根据患者是否使用火把花根片治疗分为对照组、观察组,每组50例,对照组仅行常规治疗,观察组加用火把花根片治疗。比较2组患者治疗前后24 h尿蛋白总量(urine protein quantitation,UTP)、肝肾功能指标[血清白蛋白(serum albumin,ALB)、谷丙转氨酶(glutamicpyruvic transaminase,GPT)、血肌酐(serum creatinine,Scr)、内生肌酐清除率(creatinine clearance,CCr)]、血脂指标[三酰甘油(triacylglycerol,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白(high density lipoprotein,HDL-C)、低密度脂蛋白(low density lipoprotein,LDL-C)]、免疫功能指标[T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)值)],并比较2组疗效、不良反应发生率。结果治疗后,观察组UTP水平[(1.22±0.21)g·24 h^(−1) vs.(2.36±0.31)g·24 h^(−1)]、Scr水平[(107.98±10.14)μmol·L^(−1)vs.(123.42±12.31)μmol·L^(−1)]降低,ALB水平[(46.98±5.64)g·L^(−1)vs.(43.62±3.41)g·L^(−1)]、CCr水平[(49.98±6.57)mL·min^(−1)vs.(42.13±4.35)mL·min^(−1)]升高,差异具有统计学意义(t=21.530、6.846、8.125、3.605、7.045,均P<0.05)。治疗后观察组GPT略低于对照组,但差异无统计学意义(P>0.05)。治疗后,观察组TG[(1.43±0.21)mmol·L^(−1)vs.(2.00±0.25)mmol·L^(−1)]、TC[(4.72±0.35)mmol·L^(−1)vs.(5.08±0.40)mmol·L^(−1)]、LDL-C[(3.01±0.14)mmol·L^(−1)vs.(3.26±0.17)mmol·L^(−1)]低于对照组,HDL-C[(1.69±0.35)mmol·L^(−1)vs.(1.40±0.22)mmol·L^(−1)]高于对照组,差异具有统计学意义(t=12.340、4.789、8.027、4.960,均P<0.05)。观察组CD4^(+)比例[(44.53%±5.16%)vs.(40.21%±4.35%)]、CD4^(+)/CD8^(+)值[(1.78±0.31)vs.(1.36±0.24)]升高,CD8^(+)比例[(24.36%±2.15%)vs.(28.98%±2.21%)]降低,差异具有统计学意义(t=4.526、7.575、10.600,P<0.05)。与对照组比较,观察组的治疗总有效率[96.00%vs.82.00%]升高,差异具有统计学意义(χ^(2)=5.005,P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论火把花根片可降低慢性肾病患者的尿蛋白水平,提高免疫功能,改善血脂,促进患者肾功能恢复,且不会引起肝功能损伤,应用有效且安全。

Objective To study the efficacy of Huobahuagen Tablets in the treatment of chronic kidney disease and its impact on urine protein,liver and kidney function and blood lipids etc in patients.Methods A retrospective Cohort study was performed to analyze the data of 100 patients with chronic kidney disease admitted to our hospital from June 2022 to April 2023.According to the treatment regime,the patients were divided into control group and study group,each with 50 cases.The control group only received conventional treatment,while the study group additionally received Huobahuagen Tablets.The levels of total urinary protein(UTP)in 24 hours,the liver and kidney function indicators[serum albumin(ALB),glutamic pyruvic transaminase(GPT),serum creatinine(Scr),and endogenous creatinine clearance rate(CCr)],the blood lipids[triacylglycerol(TG),total cholesterol(TC),high-density lipoprotein(HDL-C),and low-density lipoprotein(LDL-C)],and the immune function indicators[T lymphocyte subsets(CD4^(+),CD8^(+),and CD4^(+)/CD8^(+))]were compared between the 2 groups before and after treatment,and the efficacy and incidence of adverse reactions were also compared.Results After treatment,compared with the control group,the UTP levels[(1.22±0.21)g·24 h^(−1) vs.(2.36±0.31)g·24 h^(−1)]and Scr levels[(107.98±10.14)μmol·L^(−1)vs.(123.42±12.31)μmol·L^(−1)]of the study group decreased,while the ALB levels[(46.98±5.64)g·L^(−1)vs.(43.62±3.41)g·L^(−1)],and CCr levels[(49.98±6.57)mL·min^(−1)vs.(42.13±4.35)mL·min^(−1)]increased,with statistically significant differences(t=21.530,6.846,8.125,3.605,7.045,all P<0.05).After treatment,the GPT of the study group were slightly lower than those of the control group,but the difference was not statistically significant(P>0.05).After treatment,compared with the control group,the TG[(1.43±0.21)mmol·L^(-1) vs.(2.00±0.25)mmol·L^(−1)],the TC[(4.72±0.35)mmol·L^(−1)vs.(5.08±0.40)mmol·L^(−1)],and the LDL-C[(3.01±0.14)mmol·L^(−1)vs.(3.26±0.17)mmol·L^(−1)]of the study group were lower,while the HDL-C[(1.69±0.35)mmol·L^(−1)vs.(1.40±0.22)mmol·L^(−1)]was higher with significant difference(t=12.340,4.789,8.027,4.960,all P<0.05).The proportion of CD4^(+)[(44.53%±5.16%)vs.(40.21%±4.35%)],and the CD4^(+)/CD8^(+)ratio[(1.78±0.31)vs.(1.36±0.24)]of the study group increased,while the CD8^(+)ratio[(24.36%±2.15%)vs.(28.98%±2.21%)]decreased with significant difference(t=4.526,7.575,10.600,P<0.05).Compared with the control group,the total effective rate of the study group was higher(96.00%vs.82.00%),and the difference was statistically significant(χ^(2)=5.005,P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Huohuagen Tablets can reduce the level of urinary protein,improve immune function,improve lipid metabolism,promote the recovery of renal function in patients with chronic kidney disease,and do not cause liver function damage.The tablets are effective and safety.