摘要
目的:观察血清肌酸激酶同工酶(CK-MB)联合血细胞分析中性粒细胞/淋巴细胞(NLR)水平预测慢性心力衰竭患者预后的价值。方法:选取2019年2月-2021年12月本单位收治的慢性心力衰竭患者共90例,统计患者预后不良发生率并根据结果分为预后良好组和预后不良组,对比预后良好组和预后不良组血清CK-MB和NLR水平,Logistic多元回归分析明确血清CK-MB、NLR水平与慢性心力衰竭患者预后不良的关系,受试者工作特征(ROC)曲线评价血清CK-MB、NLR单独及联合预测慢性心力衰竭患者预后不良的效能。结果:慢性心力衰竭患者90例患者中有41例患者发生预后不良,慢性心力衰竭患者预后不良发生率为45.56%(41/90)。慢性心力衰竭患者预后不良与预后良好者性别、年龄、合并高血压、合并糖尿病、饮酒、吸烟、贫血、WBC水平、Hb水平对比无统计学差异(P>0.05),预后不良组血清CK-MB、NLR均高于预后良好者(P<0.05)。将慢性心力衰竭患者预后不良赋值为1,预后良好赋值为0,进行Logistic多元回归分析显示,血清CK-MB、NLR均是慢性心力衰竭患者预后不良的危险因素(P<0.05)。血清CK-MB、NLR水平联合预测慢性心力衰竭患者预后不良的灵敏度均高于单独预测(P<0.05),其特异度与单独预测比较差异均无统计学意义(P0.05),其AUC均高于单独预测(Z=3.854,P=0.002;Z=2.587,P=0.003)。结论:慢性心力衰竭患者血清CK-MB、NLR水平高,预后差,且血清CK-MB、NLR均是预后不良的危险因素,血清CK-MB、NLR联合可理想预测其预后。
Objective:To evaluate the prognostic value of serum creatine kinase isoenzyme(CK-MB)combined with serum neutrophil/lymphocyte(NLR)levels in patients with chronic heart failure.Methods:A total of 90 patients with chronic heart failure admitted to our unit from February 2019 to December 2021 were selected to make statistics on the incidence of poor prognosis and divided into good prognosis group and poor prognosis group according to the results.Serum CK-MB and NLR levels of good prognosis group and poor prognosis group were compared.Multiple Logistic regression analysis determined the relationship between serum CK-MB and NLR levels and poor prognosis in patients with chronic heart failure.Receiver operating characteristic(ROC)curve evaluated the eficacy of serum CK-MB and NLR alone and in combination in predicting poor prognosis in patients with chronic heart failure.Results:Among 90 patients in the observation group,41 patients had poor prognosis,and the incidence of poor prognosis in the observation group was 45.56%(41/90).There were no significant differences in gender,age,hypertension,diabetes,drinking,smoking,anemia,WBC level and Hb level between patients with poor prognosis and patients with good prognosis(P>0.05).Serum CK-MB and NLR in patients with poor prognosis were higher than those in patients with good prognosis(P<0.05).The poor prognosis of patients with chronic heart failure was assigned as 1,and the good prognosis was assigned as O.Logistic multiple regression analysis showed that serum CK-MB and NLR were risk factors for poor prognosis of patients with chronic heart failure(P<0.05):The sensitivity of the combined prediction of serum CK-MB and NLR was higher than that of the single prediction(P<0.05),there was no significant difference in the specificity between the two groups(P>0.05),and the AUC was higher than that of the single prediction(Z=3.854,P=0.002,Z-2.587,P=0.003):Conclusion:The serum CK-MB and NLR levels in patients with chronic heart failure are high and the prognosis is poor,and serum CK-MB and NLR are both risk factors for poor prognosis.The combination of serum CK-MB and NLR can predict the prognosis ideally.
作者
张巍巍
杨露
ZHANG Wei-wei;YANG Lu(Nantong Ruici Hospital Laboratory Department,Jiangsu Nantong 226010)
出处
《医学检验与临床》
2024年第2期18-22,共5页
Medical Laboratory Science and Clinics
关键词
慢性心力衰竭
中性粒细胞/淋巴细胞
肌酸激酶同工酶
预后不良
Chronic heart failure
Neutrophil/lymphocyte
Creatine kinase isoenzyme
Poor prognosis
Chronic heart failure