伴躯体症状抑郁症患者磁共振脑灰质体积异常表现

Abnormal gray matter volume of MRI in the somatic symptoms of depression

目的 采用基于体素的形态学分析(voxel-based morphometry,VBM)比较伴和不伴躯体症状抑郁症患者大脑灰质体积变化,探索伴躯体症状抑郁症患者在MRI上特有表现。方法 纳入52例抑郁症患者,根据入组时健康问卷躯体症状群量表评分是否>9分将其分为伴躯体症状组和不伴躯体症状组,同时纳入性别、年龄匹配的健康志愿者40名作为对照组。所有被试予MRI扫描,采用VBM方法比较各组大脑灰质体积的差异。结果 与对照组相比,伴躯体症状组右颞上回灰质体积增加,右眶额下回、右颞下回、左眶额下回、左颞上回体积减少(P<0.001),不伴躯体症状组右颞中回灰质体积增加,右颞上回、右颞下回体积减少(P<0.01)。抑郁症患者中,伴躯体症状组右舌回、左扣带回的体积较不伴躯体症状组增加(P<0.01)。结论 抑郁症伴躯体症状患者在VBM-MRI上表现为舌回、扣带回体积增加。

Objective To explore specific magnetic resonance imaging(MRI)features of somatic symptoms in depression by comparing the differences of brain gray matter volume in depression patients with and without somatic symptoms using voxel-based morphometry(VBM).Methods A total of 52 depression patients were recruited and divided into somatic and no somatic symptoms group according to the patient health questionnaire-15 score(>9 and≤9,respectively).Forty gender-age-matched healthy volunteers were recruited as the control group.All subjects underwent MRI scanning.Imaging data were analyzed to explore the differences in brain gray matter between groups using VBM.Results Compared with control group,gray matter volume increased in the right superior temporal gyrus,and decreased in the right inferior orbitofrontal gyrus,right inferior temporal gyrus,left inferior orbitofrontal gyrus,and left superior temporal gyrus for depressive patients with somatic symptoms(P<0.001);gray matter volume increased in the right middle temporal gyrus,and decreased in the right superior temporal gyrus and right inferior temporal gyrus for depressive patients without somatic symptoms(P<0.001).Only the volume in the right tongue and left cingulate gyrus increased in depressive patients with somatic symptoms compared with that in patients without somatic symptoms(P<0.01).Conclusion VBM-MRI has demonstrated increased volume in the tongue and cingulate gyrus in the somatic symptoms of depression.