水飞蓟素药物递送系统的研究进展

Advances in a drug delivery system for silymarin

水飞蓟素具有保护肝细胞的作用,但其肠通透性低、水溶性差,口服生物利用度较低,很大程度限制了在临床上的应用。近年来,各种药物递送技术改善了水飞蓟素的生物利用度、控缓释性,实现了药物靶向性以及减毒等作用,使水飞蓟素可应用范围更广泛。该综述从载体方面统计梳理了近几年来水飞蓟素药物递送技术的研究进展以及存在的问题。结果表明脂质体、脂质纳米粒载体、乳剂(包括自微乳化给药系统与纳米乳)、聚合物载体(包括壳聚糖与聚合物胶束)、无机纳米载体(包括铁纳米粒、金纳米粒、硅纳米粒)、蛋白质载体和水凝胶等药物递送系统研究较多,为水飞蓟素的开发提供了一定的参考。

Silymarin possesses the protective effect on hepatocytes from injuries,but its low intestinal permeability,poor water solubility and low oral bioavailability limit its clinical application to a large extent.In recent years,various drug delivery technologies have improved the bioavailability,controlled and sustained release of silymarin,achieved drug targeting and toxicity reduction,and made silymarin more widely applicable.In this paper,the research progresses and existing problems on silymarin drug delivery technologies in recent years are statistically sorted out from the perspective of carriers.The results show that there are many studies on drug delivery systems such as liposomes,lipid nanoparticl,emulsions(including self-microemulsifying drug delivery systems and nanoemulsions),polymer carriers(including chitosan and polymer micelles),inorganic nanocarriers(including iron nanoparticles,gold nanoparticles,and silicon nanoparticles),protein carriers and hydrogels,which provides a certain reference for the development of silymarin.