抗肿瘤核苷类似物研究进展

Advances in anti-tumor nucleoside analogs

癌症是一种以细胞异常增殖为特征的疾病,全球大约有六分之一的死亡是由癌症造成的。化疗是目前癌症治疗的主要手段之一,其中核苷类似物在化疗药物中占重要地位,主要结构为嘌呤或嘧啶核苷。目前,临床常用的药物并不能长久有效地控制癌症进展,而且核苷类似物存在选择性低,副作用较大等缺点,具有很大的改造空间,是药物研究的热点之一。本文论述了核苷类似物分类以及近年的研究进展。

Cancer is a disease characterized by abnormal cell proliferation,and about one-sixth of mortalities are caused by cancer.Chemotherapy is one of the main means in anti-cancer treatment,in which nucleoside analogs play a major role.At present,the clinically used nucleoside analogs cannot effectively control cancer for a long time due to the lack of selectivity and relatively high side effects,thus much progress has been made for the improvement of the class of drugs.This article discusses the classification of nucleoside analogs and the research progress in recent years.