脓毒症中调控髓源性抑制细胞的非编码RNA及相关受体研究进展

Research progress on non‑coding RNA and related receptors regulating myeloid‑derived suppressor cells in sepsis

髓源性抑制细胞(MDSC)在脓毒症早期能够限制过度炎症反应,但在脓毒症晚期加剧免疫抑制。文章主要综述了MDSC在脓毒症发展过程中受微RNA(miRNA)‑21、miRNA‑181b、miRNA‑375、miRNA‑150、Hotairm1等非编码RNA(ncRNA)及白细胞介素‑1受体(IL‑1R)、Toll样受体(TLR)、肿瘤坏死因子受体(TNFR)、程序性细胞死亡受体‑1(PD‑1)、G蛋白耦联胆汁酸受体5(TGR5)、肝脏X受体(LXR)和CC趋化因子受体2(CCR2)等受体调控,从而发挥免疫抑制作用,为寻找治疗脓毒症的靶标提供一定的理论依据。

Myeloid‑derived suppressor cell(MDSC)are capable of limiting hyper‑inflammation during the early stages of sepsis,but exacerbate immunosuppression in the late stages of sepsis.This paper mainly reviews that,during the development of sepsis,MDSC are regulated by non‑coding RNAs such as microRNA(miRNA)‑21,miRNA‑181b,miRNA‑375,miRNA‑150 and Hotairm1,as well as receptors such as interleukin‑1 receptor(IL‑1R),Toll‑like receptor(TLR),tumor necrosis factor receptors(TNFR),programmed cell death receptor‑1(PD‑1),G protein‑coupled bile acid receptor(TGR5),liver X receptor(LXR),and C‑C motif chemokine receptor 2(CCR2),thereby exerting immune‑suppressing effect.These findings provide certain theoretical evidence for searching the therapeutic targets for sepsis.