前列腺素在动脉导管未闭中的作用研究进展

Advances in the role of prostaglandins in patent ductus arteriosus

动脉导管是胎儿血液循环的重要生命通道。前列腺素(prostaglandins,PG)参与了胎儿时期动脉导管的扩张以及出生后动脉导管的解剖学重塑。动脉导管未闭(patent ductus arteriosus,PDA)是早产儿较为常见的先天性心脏病之一。目前通过抑制局部PG合成是临床上治疗PDA的主要手段,其中吲哚美辛和布洛芬是最常使用的药物,但不良反应较多,因此,PG合成途径的其他靶点成为研究者的重点关注。该文通过复习相关文献,结合PG在不同时期对动脉导管的生理作用,对当前治疗PDA的药物及其相关研究进展进行综述,以期对该病的治疗和未来研究提供新的思路。

The ductus arteriosus is an important lifeline for fetal circulation.Prostaglandins(PG)are involved in the dilatation of the ductus arteriosus during fetal life as well as the anatomical remodeling of the ductus arteriosus after birth.Patent ductus arteriosus(PDA)is a common congenital heart disease in preterm infants.The treatment by inhibiting local PG synthesis is currently the principal means of clinical practice,with indomethacin and ibuprofen being the most commonly applied drugs,but the prevalence of adverse effects has led scholars to focus on other targets of the PG synthesis pathway.This paper reviews relevant medications and combines the physiological effects of PG on ductus arteriosus in different stages to summarize the current drugs of treating PDA and their related research advances,with the aim to provide new strategies for the treatment and future research of this condition.