呼吸机高频振荡通气系统仿真建模与分析

Simulation Modeling and Analysis of High-frequency Oscillation Ventilation System of Ventilator

提出一种综合呼吸机、呼吸管路、人体呼吸系统的呼吸机高频振荡通气系统仿真模型。根据呼吸机气动方案,以及呼吸系统的ExtendedRIC模型,应用Simscape多域物理建模软件,搭建呼吸机高频振荡通气系统仿真模型。对于呼吸机气动回路中的各零部件,通过使用Simscape软件相应模块进行模拟。人体呼吸系统根据工作机理,选用适当的模块组合进行模拟。将呼吸机模型与呼吸系统模型进行连接,并加入相应控制系统,形成完整的仿真模型。使用由高频振荡呼吸机与ASL5000主动模拟肺组成的试验平台,对仿真模型进行性能对比,以验证合理性。在HFO+CPAP和HFO+IPPV模式下,仿真模型测得的压力、流量、潮气量波形与试验平台测得的相应数据波形相比,偏差较小。将仿真与试验数据导入SPSS数据分析软件,进行比较分析,发现仿真与试验数据具有较好的一致性。呼吸机高频振荡通气系统仿真模型能够有效模拟呼吸机高频振荡通气时与患者呼吸系统间的相互作用,突破了现有通气模型仅考虑人体呼吸系统的局限性,具有实用价值。

A simulation model of high-frequency oscillation ventilation system of the ventilator was proposed,which integrates ventilator,breathing pipeline and human respiratory system.According to the ventilator pneumatic scheme and the Extended RIC model of the respiratory system,the simulation model of high-frequency oscillation ventilation system of the ventilator was constructed by using the Simscape multi-domain physical modeling software.For each component in the pneumatic circuit of the ventilator,the simulation was carried out by using the corresponding module of Simscape software.The human respiratory system was simulated by using the appropriate combination of modules according to the working mechanism.The ventilator model was connected with the respiratory system model,and the corresponding control system was added to form a complete simulation model.The performance of the simulation model was compared by using a test platform that consists of a high-frequency oscillatory ventilator and an ASL5000 active simulated lung,and the rationality was verified.Under the HFO+CPAP mode and the HFO+IPPV mode,the pressure,flow rate,and tidal volume waveforms obtained by the simulation model show less deviation compared with the corresponding data waveforms measured by the test platform.The simulation and test data were imported into the SPSS data analysis software and compared and analyzed.It was found that the simulation and test data are in good consistence.The simulation model of high-frequency oscillation ventilation system of the ventilator can effectively simulate the interaction between the high-frequency oscillation ventilation system and the patient's respiratory system,which breaks the limitation of existing ventilation model that can only consider the human respiratory system,and has practical value.